CTSG and CAMP

Number of citations of the paper that reports this interaction (PubMedID 11389039)
195

Data Source:
HPRD (in vivo, in vitro)

		CTSG	CAMP
Description		cathepsin G	cathelicidin antimicrobial peptide
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Plasma Membrane Cell Surface Cytoplasmic Stress Granule Secretory Granule Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome	Extracellular Region Extracellular Space Specific Granule Lumen Specific Granule Extracellular Exosome Tertiary Granule Lumen
	Molecular Function	Serine-type Endopeptidase Activity Protein Binding Heparin Binding Peptidase Activity Serine-type Peptidase Activity	Lipopolysaccharide Binding
	Biological Process	Angiotensin Maturation Protein Phosphorylation Proteolysis Immune Response Antimicrobial Humoral Response Antibacterial Humoral Response Extracellular Matrix Disassembly Neutrophil Degranulation Cellular Protein Metabolic Process Positive Regulation Of Immune Response Defense Response To Gram-negative Bacterium Defense Response To Fungus Neutrophil Mediated Killing Of Gram-positive Bacterium Cellular Response To Lipopolysaccharide	Innate Immune Response In Mucosa Antimicrobial Humoral Response Antibacterial Humoral Response Defense Response To Bacterium Neutrophil Degranulation Innate Immune Response Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium Killing By Host Of Symbiont Cells Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide
Pathways		Degradation of the extracellular matrix Activation of Matrix Metalloproteinases Metabolism of Angiotensinogen to Angiotensins Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Interleukin-1 processing Neutrophil degranulation Antimicrobial peptides Suppression of apoptosis Purinergic signaling in leishmaniasis infection	Neutrophil degranulation Antimicrobial peptides
Drugs		Bis-Napthyl Beta-Ketophosphonic Acid 2-[3-({Methyl[1-(2-Naphthoyl)Piperidin-4-Yl]Amino}Carbonyl)-2-Naphthyl]-1-(1-Naphthyl)-2-Oxoethylphosphonic Acid	Selenocysteine
Diseases
GWAS		Congenital heart disease (maternal effect) ( 28468790) Conotruncal heart defects (maternal effects) ( 28468790)	Blood protein levels ( 30072576 28240269)
Interacting Genes		28 interacting genes: AGT C3 CAMP CASP7 CXCL12 CXCR4 ERBIN F2R F2RL1 F2RL2 F5 GP1BA IGFBP3 KNG1 KRT31 LRP1 NOTCH2NLA PARP1 PPBP SDC1 SELPLG SERPINA1 SERPINA3 SERPINB13 SERPINB4 SERPIND1 THBS1 VCAM1	8 interacting genes: CTSG ELANE FPR2 GPX1 LBP MAPK8 PRTN3 RHOA
Entrez ID		1511	820
HPRD ID		00289	02722
Ensembl ID		ENSG00000100448	ENSG00000164047
Uniprot IDs		P08311	A0A384NPR0 J3KNB4 P49913
PDB IDs		1AU8 1CGH 1KYN 1T32	2FBS 2FBU 2FCG 2K6O 2LMF 2NA3 4EYC 5NMN 5NNK 5NNM 5NNT 5XNG 5XRX 6BIV 6BIX
Enriched GO Terms of Interacting Partners?
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