ADRA2B and EIF2B1

Number of citations of the paper that reports this interaction (PubMedID 9235896)
14

Data Source:
HPRD (in vivo, in vitro)

		ADRA2B	EIF2B1
Description		adrenoceptor alpha 2B	eukaryotic translation initiation factor 2B subunit alpha
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GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Cell Surface	Cytoplasm Cytosol Eukaryotic Translation Initiation Factor 2B Complex Plasma Membrane Membrane
	Molecular Function	Adrenergic Receptor Activity Alpha2-adrenergic Receptor Activity Protein Binding Epinephrine Binding	Translation Initiation Factor Activity Guanyl-nucleotide Exchange Factor Activity Protein Binding Identical Protein Binding
	Biological Process	Activation Of MAPK Activity Regulation Of Vascular Smooth Muscle Contraction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Cell-cell Signaling Female Pregnancy Behavior Negative Regulation Of Norepinephrine Secretion Platelet Activation Activation Of Protein Kinase B Activity Negative Regulation Of Epinephrine Secretion Receptor Transactivation Positive Regulation Of MAPK Cascade Positive Regulation Of Neuron Differentiation Positive Regulation Of Blood Pressure Positive Regulation Of Uterine Smooth Muscle Contraction Adrenergic Receptor Signaling Pathway Adenylate Cyclase-activating Adrenergic Receptor Signaling Pathway	Translational Initiation Regulation Of Translational Initiation Response To Heat Response To Glucose Oligodendrocyte Development Response To Peptide Hormone T Cell Receptor Signaling Pathway
Pathways		Adrenoceptors Adrenaline signalling through Alpha-2 adrenergic receptor G alpha (i) signalling events G alpha (z) signalling events	Recycling of eIF2:GDP
Drugs		Amphetamine Bethanidine Ziprasidone Cabergoline Ropinirole Etomidate Olanzapine Clozapine Norepinephrine Phenylpropanolamine Loxapine Pramipexole Prazosin Chlorpromazine Brimonidine Nortriptyline Amoxapine Clonidine Lisuride Guanabenz Epinephrine Ergotamine Tizanidine Apomorphine Trimipramine Risperidone Tolazoline Fenoldopam Dobutamine Phenoxybenzamine Maprotiline Oxymetazoline Apraclonidine Guanfacine Ergoloid mesylate Carvedilol Doxepin Desipramine Pergolide Bromocriptine Quetiapine Aripiprazole Paliperidone Ephedra Mephentermine Yohimbine Methotrimeprazine Methamphetamine Dronedarone Rotigotine OPC-28326 Epicept NP-1 Mianserin Asenapine Droxidopa Esmirtazapine Xylometazoline Levonordefrin Dosulepin Etoperidone Cirazoline Setiptiline Tiapride
Diseases			Leukoencephalopathy with vanishing white matter; Vanishing white matter disease; Childhood ataxia with diffuse central nervous system hypomyelination (CACH); Cree leukoencephalopathy (CLE)
GWAS			Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age >50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		9 interacting genes: ADAMTS1 EIF2B1 GGA1 GGA2 GGA3 GNAI2 PPP1R9B UCHL1 YWHAZ	15 interacting genes: ADRA2A ADRA2B ADRA2C ADRB2 ARL4D BZW2 CREBBP EIF2B2 EIF2S1 EIF2S2 EPM2A GORASP2 MRPL4 NTAQ1 RD3
Entrez ID		151	1967
HPRD ID		00086	09458
Ensembl ID		ENSG00000274286	ENSG00000111361
Uniprot IDs		P18089	Q14232
PDB IDs		2CVA	3ECS 6CAJ 6EZO 6K71 6K72 6O81 6O85 6O9Z
Enriched GO Terms of Interacting Partners?
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