HSCB and BBS4

Number of citations of the paper that reports this interaction (PubMedID 18000879)
7

Data Source:
BioGRID (two hybrid)

		HSCB	BBS4
Description		HscB mitochondrial iron-sulfur cluster cochaperone	Bardet-Biedl syndrome 4
Image			No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Cytoplasm Mitochondrion Cytosol	Pericentriolar Material Photoreceptor Outer Segment Photoreceptor Inner Segment Cell Nucleus Centrosome Centriole Cytosol Cilium Motile Cilium Photoreceptor Connecting Cilium Centriolar Satellite BBSome Ciliary Transition Zone Ciliary Basal Body Ciliary Membrane Non-motile Cilium
	Molecular Function	ATPase Activator Activity Molecular_function Protein Binding Identical Protein Binding Metal Ion Binding Chaperone Binding	RNA Polymerase II Repressing Transcription Factor Binding Microtubule Motor Activity Protein Binding Dynactin Binding Alpha-tubulin Binding Beta-tubulin Binding
	Biological Process	Iron-sulfur Cluster Assembly Positive Regulation Of ATPase Activity [2Fe-2S] Cluster Assembly Protein Complex Oligomerization Protein Maturation By Iron-sulfur Cluster Transfer	Microtubule Cytoskeleton Organization Mitotic Cytokinesis Neuron Migration Neural Tube Closure Retina Homeostasis Heart Looping Negative Regulation Of Systemic Arterial Blood Pressure Centrosome Cycle Spermatid Development Visual Perception Sensory Perception Of Smell Negative Regulation Of Gene Expression Protein Transport Dendrite Development Regulation Of Lipid Metabolic Process Ventricular System Development Striatum Development Hippocampus Development Cerebral Cortex Development Adult Behavior Negative Regulation Of Actin Filament Polymerization Melanosome Transport Regulation Of Cytokinesis Protein Localization To Organelle Negative Regulation Of GTPase Activity Microtubule Anchoring At Centrosome Social Behavior Photoreceptor Cell Outer Segment Organization Negative Regulation Of Appetite By Leptin-mediated Signaling Pathway Positive Regulation Of Multicellular Organism Growth Fat Cell Differentiation Photoreceptor Cell Maintenance Positive Regulation Of Cilium Assembly Retinal Rod Cell Development Intracellular Transport Brain Morphogenesis Sensory Processing Maintenance Of Protein Location In Nucleus Regulation Of Stress Fiber Assembly Cilium Assembly Regulation Of Cilium Beat Frequency Involved In Ciliary Motility Face Development Fat Pad Development Protein Localization To Cilium Protein Localization To Centrosome Regulation Of Non-motile Cilium Assembly Protein Localization To Photoreceptor Outer Segment Non-motile Cilium Assembly
Pathways		Mitochondrial protein import Mitochondrial protein import Mitochondrial iron-sulfur cluster biogenesis	BBSome-mediated cargo-targeting to cilium
Drugs
Diseases			Bardet-Biedl syndrome (BBS)
GWAS		Breast size ( 27182965) Diastolic blood pressure ( 27841878) Esophageal cancer and gastric cancer ( 20729852) Pancreatic cancer ( 25086665) Red cell distribution width ( 27863252) Systolic blood pressure ( 27841878)	Body mass index ( 29273807 28448500) Body mass index (joint analysis main effects and physical activity interaction) ( 28448500) Body mass index in physically active individuals ( 28448500) Theory of mind score in adolescence (Emotional Triangles Task) ( 29472613) Triglycerides ( 30275531) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		6 interacting genes: AGTRAP BBS1 BBS2 BBS4 FBN1 ISCU	15 interacting genes: ACTB BHMT CALCA DCTN1 EEF1A1 EIF3A EPAS1 EXOC7 FHOD1 HSCB KRT18 MYOG PAX2 PCM1 REL
Entrez ID		150274	585
HPRD ID		16289	08982
Ensembl ID		ENSG00000100209	ENSG00000140463
Uniprot IDs		A0A384NYJ4 B0QYH2 Q8IWL3	A0A0S2Z3A9 Q96RK4
PDB IDs		3BVO
Enriched GO Terms of Interacting Partners?
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