GLIS1 and SOX3

Number of citations of the paper that reports this interaction (PubMedID 28205554)
32

Data Source:
BioGRID (fluorescent resonance energy transfer)

		GLIS1	SOX3
Description		GLIS family zinc finger 1	SRY-box transcription factor 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus	Nuclear Chromatin Nucleus Nucleoplasm Nuclear Transcription Factor Complex
	Molecular Function	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Metal Ion Binding	RNA Polymerase II Core Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Osteoblast Differentiation Negative Regulation Of Cell Fate Commitment Fat Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II	Regulation Of Transcription, DNA-templated Regulation Of Transcription By RNA Polymerase II Central Nervous System Development Sensory Organ Development Sex Determination Anatomical Structure Morphogenesis Hypothalamus Development Pituitary Gland Development Cell Differentiation Negative Regulation Of Neuron Differentiation Face Development Negative Regulation Of Nucleic Acid-templated Transcription
Pathways			Deactivation of the beta-catenin transactivating complex
Drugs
Diseases			Septo-optic dysplasia Pituitary Dwarfism (PD); Isolated growth hormone deficiency (IGHD); Short Stature and Pituitary Defects (SSPD); Insulin-like growth factor 1 deficiency (IGFD) 46,XX disorders of sex development (Disorders of gonadal development), including: Ovotesticular DSD; Testicular DSD; Ovarian dysgenesis Syndromic X-linked mental retardation, including: Turner type (MRXST); Siderius type (MRXSSD) ; Cabezas type (MRXC); Raymond type (MRXSR); Type10 (MRXS10); Type14 (MRXS14); Mental retardation with isolated growth hormone deficiency (MRGH)
GWAS		Cerebrospinal fluid AB1-42 levels ( 28247064) Digit length ratio ( 29659830) Digit length ratio (left hand) ( 29659830) Digit length ratio (right hand) ( 29659830) Hand grip strength ( 29691431 29313844) Mitral valve prolapse ( 26301497) Monobrow ( 27182965) Nicotine use ( 23942779) Non-substance related behavioral disinhibition ( 23942779) Nose size ( 27182965) Response to statin therapy ( 20339536)	Height ( 31562340)
Interacting Genes		11 interacting genes: ARNT CDK6 CDKN2A GLIS2 LATS2 MYC NFIC RELA SOX3 TCF3 TEAD2	12 interacting genes: AURKA CDKN2A DACH1 GLIS1 GLIS2 MYC NF2 NFIC NSD3 PAX6 TEAD2 TERT
Entrez ID		148979	6658
HPRD ID		13581	02432
Ensembl ID		ENSG00000174332	ENSG00000134595
Uniprot IDs		A0A0D9SEX9 Q8NBF1	P41225
PDB IDs
Enriched GO Terms of Interacting Partners?
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