SPC24 and SKA2

Number of citations of the paper that reports this interaction (PubMedID 22371557)
54

Data Source:
BioGRID (two hybrid)

		SPC24	SKA2
Description		SPC24 component of NDC80 kinetochore complex	spindle and kinetochore associated complex subunit 2
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GO Annotations	Cellular Component	Condensed Chromosome Kinetochore Nucleoplasm Nucleolus Cytosol Ndc80 Complex	Condensed Chromosome Outer Kinetochore Cytosol Spindle Microtubule
	Molecular Function	Protein Binding	Protein Binding Microtubule Binding
	Biological Process	Cell Cycle Cell Division	Mitotic Cell Cycle Chromosome Segregation Regulation Of Microtubule Polymerization Or Depolymerization Cell Division
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation	Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Cortisol levels (saliva) ( 28843169) HDL cholesterol ( 23505323) Intraocular pressure ( 29617998) Lipid traits ( 24386095) Low density lipoprotein cholesterol levels ( 30718733) Voxel-wise structural brain imaging measurements in Alzheimerâ€™s disease ( 31095298)	Cognitive function ( 25644384) Testicular germ cell tumor ( 23666239)
Interacting Genes		5 interacting genes: APP PSEN2 SKA1 SKA2 SKA3	4 interacting genes: HMOX2 PRKD3 SKA1 SPC24
Entrez ID		147841	348235
HPRD ID		15464	13306
Ensembl ID		ENSG00000161888	ENSG00000182628
Uniprot IDs		B4E086 Q8NBT2	J3KSP0 Q8WVK7
PDB IDs		2VE7 3IZ0	4AJ5
Enriched GO Terms of Interacting Partners?
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