CSNK2A2 and MGMT

Number of citations of the paper that reports this interaction (PubMedID 10667577)
9

Data Source:
BioGRID (enzymatic study)

		CSNK2A2	MGMT
Description		casein kinase 2 alpha 2	O-6-methylguanine-DNA methyltransferase
Image
GO Annotations	Cellular Component	Chromatin Acrosomal Vesicle Nucleus Nucleoplasm Cytosol Plasma Membrane PcG Protein Complex	Nucleus Nucleoplasm Membrane
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Protein N-terminus Binding	DNA Binding Methylated-DNA-[protein]-cysteine S-methyltransferase Activity Methyltransferase Activity DNA-methyltransferase Activity Metal Ion Binding
	Biological Process	Protein Folding Phosphatidylcholine Biosynthetic Process Apoptotic Process Cell Cycle Spermatogenesis Wnt Signaling Pathway Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Cerebral Cortex Development Regulation Of Cell Cycle Liver Regeneration Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Autophagy Of Mitochondrion Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	DNA Ligation DNA Repair DNA Methylation DNA Dealkylation Involved In DNA Repair Negative Regulation Of Apoptotic Process Positive Regulation Of Double-strand Break Repair
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	MGMT-mediated DNA damage reversal
Drugs		[1-(6-{6-[(1-methylethyl)amino]-1H-indazol-1-yl}pyrazin-2-yl)-1H-pyrrol-3-yl]acetic acid	L-Cysteine Zinc S-Methylcysteine Benzylcysteine Dinitrochlorobenzene
Diseases
GWAS		Primary biliary cholangitis ( 28425483) Rosacea symptom severity ( 29771307) Systemic lupus erythematosus ( 28714469) Telomere length ( 24795349)	Alzheimer's disease in APOE e4- carriers ( 25778476) Anorexia nervosa ( 31308545) Chronotype ( 30696823) Drug experimentation measurement ( 30718321) Gut microbiota (functional units) ( 27694959) Hand grip strength ( 29691431 29313844) Heel bone mineral density ( 30598549) Inflammatory skin disease ( 25574825) Intraocular pressure ( 29617998) Iris color (a* coordinate) ( 30895295) Iris color (b* coordinate) ( 30895295) Lead levels ( 26025379) Metabolite levels ( 23823483) Metabolite levels (X-11787) ( 23934736) MGMT methylation in smokers ( 26183928) Modic changes ( 30808802) Response to temozolomide ( 23047291) Tea consumption ( 31046077) Waist-to-hip circumference ratio (ever vs never smoking interaction) ( 23192594)
Interacting Genes		103 interacting genes: ABCA1 ACACA ADH1A AMFR AQP4 ARRB2 ASL ATF1 ATF2 ATG16L1 BHLHE41 BID CABP1 CALM1 CASQ2 CAV1 CDC37 CLTB CREBBP CREM CSN3 CSNK2B CTDP1 DCPS DELEC1 EEF1B2 EIF2B2 EIF2B5 EIF4EBP1 ERH FGF1 FGF2 FKBP3 FOS GOT2 GTF2A1 GTF2A1L H1-2 HDAC1 HDAC2 HDAC6 HMGA1 HMGA2 HNRNPC HSP90AA1 HSP90B1 HSPH1 IL16 KDM1A KIF1C KLF1 LAMC3 LGALS3 MAF1 MAPK14 MDM2 MGMT MS4A1 MYC MYCN MYF5 NAP1L4 NCL NR1D2 P4HB PAK1 PIN1 PIN4 PPP1R1B PPP1R2 PPP1R8 PRNP PTEN PTPN1 PTPRC RAD1 RAD9A RELA RGS19 SAT1 SLC18A2 SMURF1 SNCA SNX6 SPIB SPP1 STX1A TCF7L2 TCOF1 TGFBR1 TGM2 TOP1 TP53 TP63 TRIM41 TTLL12 UBE2R2 WAS XRCC1 ZNF219 ZNF423 ZNF670 ZNHIT3	9 interacting genes: CREBBP CSNK2A1 CSNK2A2 EP300 ESR1 PCNA PRKACA PRKCA UBA1
Entrez ID		1459	4255
HPRD ID		00279	01135
Ensembl ID		ENSG00000070770	ENSG00000170430
Uniprot IDs		P19784	B4DEE8 P16455
PDB IDs		3E3B 3OFM 3U87 5M4U 5M56 5OOI 5Y9M 5YF9 5YWM 6HMB 6HMC 6HMD 6HMQ 6QY9	1EH6 1EH7 1EH8 1QNT 1T38 1T39 1YFH
Enriched GO Terms of Interacting Partners?
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