CSNK2A1 and MAPK1

Number of citations of the paper that reports this interaction (PubMedID 19941816)
117

Data Source:
BioGRID (enzymatic study, affinity chromatography technology, pull down)

		CSNK2A1	MAPK1
Description		casein kinase 2 alpha 1	mitogen-activated protein kinase 1
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytosol Plasma Membrane Protein Kinase CK2 Complex Sin3 Complex NuRD Complex PcG Protein Complex	Extracellular Region Cell Nucleus Nucleoplasm Cytoplasm Mitochondrion Early Endosome Late Endosome Golgi Apparatus Microtubule Organizing Center Cytosol Cytoskeleton Plasma Membrane Caveola Focal Adhesion Postsynaptic Density Axon Pseudopodium Dendrite Cytoplasm Protein-containing Complex Azurophil Granule Lumen Perikaryon Mitotic Spindle Ficolin-1-rich Granule Lumen
	Molecular Function	Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Identical Protein Binding Protein N-terminus Binding Hsp90 Protein Binding	Phosphotyrosine Residue Binding Double-stranded DNA Binding Protein Serine/threonine Kinase Activity MAP Kinase Activity MAP Kinase Kinase Activity Protein Binding ATP Binding Transcription Factor Binding RNA Polymerase II CTD Heptapeptide Repeat Kinase Activity Kinase Activity Phosphatase Binding Mitogen-activated Protein Kinase Kinase Kinase Binding Identical Protein Binding
	Biological Process	Protein Folding Protein Phosphorylation Phosphatidylcholine Biosynthetic Process Apoptotic Process Cell Cycle Signal Transduction Positive Regulation Of Cell Proliferation Wnt Signaling Pathway Macroautophagy Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Positive Regulation Of Wnt Signaling Pathway Positive Regulation Of Cell Growth Negative Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Protein Catabolic Process Rhythmic Process Regulation Of Cell Cycle Chaperone-mediated Protein Folding Regulation Of Signal Transduction By P53 Class Mediator Regulation Of Chromosome Separation Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Apoptotic Signaling Pathway	MAPK Cascade Activation Of MAPKK Activity Activation Of MAPK Activity Protein Phosphorylation Apoptotic Process Chemotaxis Cellular Response To DNA Damage Stimulus Cell Cycle Signal Transduction Cell Surface Receptor Signaling Pathway Chemical Synaptic Transmission Axon Guidance Aging Learning Or Memory Fibroblast Growth Factor Receptor Signaling Pathway Regulation Of Gene Expression Positive Regulation Of Gene Expression Positive Regulation Of Peptidyl-threonine Phosphorylation Regulation Of Phosphatidylinositol 3-kinase Signaling Diadenosine Tetraphosphate Biosynthetic Process Viral Process Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Sensory Perception Of Pain Cytosine Metabolic Process Platelet Activation Regulation Of Ossification Positive Regulation Of Cell Migration Regulation Of Cellular PH Thyroid Gland Development Regulation Of Protein Stability Lipopolysaccharide-mediated Signaling Pathway Positive Regulation Of Telomere Maintenance Via Telomerase Regulation Of Stress-activated MAPK Cascade Mammary Gland Epithelial Cell Proliferation Cellular Response To Amino Acid Starvation Cellular Response To Reactive Oxygen Species Response To Nicotine Intracellular Signal Transduction Fc-epsilon Receptor Signaling Pathway Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis ERBB Signaling Pathway Positive Regulation Of Protein Import Into Nucleus Outer Ear Morphogenesis Neutrophil Degranulation Response To Exogenous DsRNA Response To Estrogen Negative Regulation Of Cell Differentiation Positive Regulation Of Translation Positive Regulation Of Transcription, DNA-templated Decidualization Thymus Development T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway Regulation Of DNA-binding Transcription Factor Activity Stress-activated MAPK Cascade Regulation Of Cytoskeleton Organization Positive Regulation Of Telomerase Activity Bergmann Glial Cell Differentiation Positive Regulation Of Cardiac Muscle Cell Proliferation Long-term Synaptic Potentiation Face Development Lung Morphogenesis Trachea Formation Labyrinthine Layer Blood Vessel Development Cardiac Neural Crest Cell Development Involved In Heart Development ERK1 And ERK2 Cascade Response To Epidermal Growth Factor Cellular Response To Cadmium Ion Cellular Response To Organic Substance Cellular Response To Tumor Necrosis Factor Caveolin-mediated Endocytosis Regulation Of Golgi Inheritance Cellular Response To Granulocyte Macrophage Colony-stimulating Factor Stimulus Regulation Of Cellular Response To Heat Cellular Response To Dopamine Positive Regulation Of Telomere Capping Regulation Of Early Endosome To Late Endosome Transport
Pathways		Synthesis of PC WNT mediated activation of DVL Condensation of Prometaphase Chromosomes Signal transduction by L1 Regulation of TP53 Activity through Phosphorylation Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding Receptor Mediated Mitophagy RUNX1 interacts with co-factors whose precise effect on RUNX1 targets is not known Regulation of PTEN stability and activity	phospho-PLA2 pathway RAF-independent MAPK1/3 activation MAPK1 (ERK2) activation Spry regulation of FGF signaling Golgi Cisternae Pericentriolar Stack Reorganization Frs2-mediated activation ERK/MAPK targets ERK/MAPK targets ERKs are inactivated Regulation of actin dynamics for phagocytic cup formation Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Oncogene Induced Senescence FCERI mediated MAPK activation Regulation of HSF1-mediated heat shock response NCAM signaling for neurite out-growth Recycling pathway of L1 RSK activation Signal transduction by L1 Activation of the AP-1 family of transcription factors Thrombin signalling through proteinase activated receptors (PARs) Negative regulation of FGFR1 signaling Negative regulation of FGFR2 signaling Negative regulation of FGFR3 signaling Negative regulation of FGFR4 signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate NADPH Oxidases RAF/MAP kinase cascade MAP2K and MAPK activation Negative feedback regulation of MAPK pathway Negative regulation of MAPK pathway Neutrophil degranulation Signaling by moderate kinase activity BRAF mutants Signaling by high-kinase activity BRAF mutants Signaling by BRAF and RAF fusions Paradoxical activation of RAF signaling by kinase inactive BRAF PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling Signal attenuation Advanced glycosylation endproduct receptor signaling Gastrin-CREB signalling pathway via PKC and MAPK ESR-mediated signaling RUNX2 regulates osteoblast differentiation Regulation of PTEN gene transcription Regulation of the apoptosome activity Estrogen-stimulated signaling through PRKCZ Estrogen-dependent nuclear events downstream of ESR-membrane signaling Estrogen-dependent nuclear events downstream of ESR-membrane signaling Suppression of apoptosis Signaling downstream of RAS mutants FCGR3A-mediated phagocytosis Growth hormone receptor signaling
Drugs		ATP (5-Oxo-5,6-Dihydro-Indolo[1,2-a]Quinazolin-7-Yl)-Acetic Acid 1,8-Di-Hydroxy-4-Nitro-Xanthen-9-One Resveratrol 1,8-Di-Hydroxy-4-Nitro-Anthraquinone Benzamidine 5,8-Di-Amino-1,4-Dihydroxy-Anthraquinone Quercetin Phosphoaminophosphonic Acid-Adenylate Ester Tetrabromo-2-Benzotriazole DIMETHYL-(4,5,6,7-TETRABROMO-1H-BENZOIMIDAZOL-2-YL)-AMINE S-METHYL-4,5,6,7-TETRABROMO-BENZIMIDAZOLE N1,N2-ETHYLENE-2-METHYLAMINO-4,5,6,7-TETRABROMO-BENZIMIDAZOLE Emodin 3,8-DIBROMO-7-HYDROXY-4-METHYL-2H-CHROMEN-2-ONE 19-(cyclopropylamino)-4,6,7,15-tetrahydro-5H-16,1-(azenometheno)-10,14-(metheno)pyrazolo[4,3-o][1,3,9]triazacyclohexadecin-8(9H)-one N,N'-DIPHENYLPYRAZOLO[1,5-A][1,3,5]TRIAZINE-2,4-DIAMINE 4-(2-(1H-IMIDAZOL-4-YL)ETHYLAMINO)-2-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(CYCLOHEXYLMETHYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-CHLOROBENZYLAMINO)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE 2-(4-ETHYLPIPERAZIN-1-YL)-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZINE-8-CARBONITRILE N-(3-(8-CYANO-4-(PHENYLAMINO)PYRAZOLO[1,5-A][1,3,5]TRIAZIN-2-YLAMINO)PHENYL)ACETAMIDE 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole 1,2,5,8-tetrahydroxyanthracene-9,10-dione Ellagic Acid	Isoprenaline Arsenic trioxide Olomoucine Phosphonothreonine Purvalanol SB220025 N,N-DIMETHYL-4-(4-PHENYL-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE N-BENZYL-4-[4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL]-1H-PYRROLE-2-CARBOXAMIDE (S)-N-(1-(3-CHLORO-4-FLUOROPHENYL)-2-HYDROXYETHYL)-4-(4-(3-CHLOROPHENYL)-1H-PYRAZOL-3-YL)-1H-PYRROLE-2-CARBOXAMIDE (3R,5Z,8S,9S,11E)-8,9,16-TRIHYDROXY-14-METHOXY-3-METHYL-3,4,9,10-TETRAHYDRO-1H-2-BENZOXACYCLOTETRADECINE-1,7(8H)-DIONE 5-(2-PHENYLPYRAZOLO[1,5-A]PYRIDIN-3-YL)-1H-PYRAZOLO[3,4-C]PYRIDAZIN-3-AMINE (1aR,8S,13S,14S,15aR)-5,13,14-trihydroxy-3-methoxy-8-methyl-8,9,13,14,15,15a-hexahydro-6H-oxireno[k][2]benzoxacyclotetradecine-6,12(1aH)-dione [4-({5-(AMINOCARBONYL)-4-[(3-METHYLPHENYL)AMINO]PYRIMIDIN-2-YL}AMINO)PHENYL]ACETIC ACID 4-[5-(4-FLUORO-PHENYL)-2-(4-METHANESULFINYL-PHENYL)-3H-IMIDAZOL-4-YL]-PYRIDINE Turpentine Ulixertinib
Diseases
GWAS		Night sleep phenotypes ( 27126917) Pursuit maintenance gain ( 29064472)	Bipolar disorder ( 31043756) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 31604244 24076602 21833088) Superior parietal cortex volume ( 31530798)
Interacting Genes		397 interacting genes: - ABCA1 ABCC1 ACACA ACAT2 ACE ACIN1 AIP AKAP8 AKT1 ALKBH5 ANP32B APEX1 APOE APP AQP4 ARL6IP4 ARMCX3 ARNT ARR3 ARRB2 ASIC3 ATF1 ATF2 ATG16L1 ATP2B1 ATP5F1A AUTS2 BCLAF1 BDP1 BHLHE41 BID BIRC6 BMS1 BRCA1 BRF1 BRMS1 C1orf109 C1R CALM1 CALU CANX CARD9 CASP2 CASQ2 CAV1 CAV2 CCDC6 CD2BP2 CD5 CDC25B CDC37 CDH1 CDK1 CDKN1A CFDP1 CHD4 CHUK CIRBP CLASP2 CLNS1A CLTB COPS2 COPS3 COPS7A CPSF6 CPSF7 CREB3L3 CREBBP CREM CSN1S1 CSN2 CSNK2B CTDP1 CTNNA1 CTNNB1 CUX2 DAXX DDIT3 DDX17 DDX21 DDX24 DDX3X DDX54 DEK DELEC1 DHX16 DHX38 DKC1 DNAJB2 DPF3 DTD1 DVL1 DVL3 ECD EEF1B2 EEF1D EGR1 EHMT2 EIF2B5 EIF2S1 EIF2S2 EIF3J EIF4B EIF4EBP1 EIF5 EIF5B ERH EXOSC9 F11R F5 FAF1 FBXO28 FGF1 FGF2 FIBP FIP1L1 FKBP3 FKBP4 FLG FNBP4 FOS FTSJ3 FXR1 GABRR1 GABRR2 GANAB GAP43 GGA1 GMFB GMNN GPI GPN1 GTF2A1 GTF2A1L GTF2F1 GYS1 HCLS1 HDAC1 HDAC2 HDAC3 HDGFL2 HDLBP HES6 HGS HIF1A HIRIP3 HMGA1 HMGA2 HMOX2 HNRNPA2B1 HNRNPC HNRNPDL HNRNPL HOXB7 HSF1 HSP90AA1 HSP90AB1 HSP90B1 HSPA4 HSPB8 HSPH1 HTATSF1 IFI16 IFRD1 IGF2R IGFBP3 IL16 INF2 IRF2 IRS1 ITCH IWS1 JUN KANK2 KDM1A KIF1C KIF5C KLF1 KPNA4 L1CAM LARP1 LEO1 LGALS3 LIG1 LRRC59 LSM14A LTV1 MAF1 MAGEA11 MAK16 MAPK1 MAPK14 MAPT MAX MAZ MCM2 MCM3 MDC1 MDM2 MEF2C MFAP1 MGMT MME MPHOSPH10 MRPL38 MRPL4 MS4A1 MSH6 MTDH MUS81 MYB MYC MYCN MYF5 MYH9 NAF1 NAP1L1 NAP1L4 NCAPD2 NCL NCOR1 NFKBIA NFKBIB NFYA NKX2-5 NMD3 NMT1 NOL3 NOLC1 NOP56 NOP58 NPM1 NRF1 NUP98 NXF1 OCLN OGDHL OGT OSBP OTUB1 PACS1 PAFAH1B1 PAK1 PAX7 PDAP1 PDCD4 PDIA6 PGR PIAS1 PIN1 PIN4 PLEKHO1 PML PNN POLR2A PPAN PPP1R1B PPP1R2 PPP1R8 PRCC PRKACB PRNP PRPF38A PSEN2 PSIP1 PSMA3 PSMA4 PSME3IP1 PTEN PTPA PTPN1 PTPRC PURB RAD1 RAD51 RAD9A RANGAP1 RBM10 RBM17 RBM33 RBMX RELA RGS19 RIOK1 RIOK2 RNF111 RNF7 RPL13 RPL5 RPL6 RPLP0 RPLP1 RPRD2 RPS18 RPS3 RPS6KB1 RRAD RRP12 RRP1B RRP9 RSF1 RSL1D1 SAFB SAP30BP SAT1 SCNN1A SEPTIN2 SERBP1 SERPINF1 SF3A1 SF3B1 SF3B2 SFPQ SHOX SLC18A2 SLC4A1AP SLIRP SMARCC2 SNCA SND1 SP1 SPATS2L SPI1 SPIB SPP1 SPTBN1 SQSTM1 SREK1 SRF SRRM1 SRRM2 SRRT SRSF10 SRSF11 SRSF2 SSB SSRP1 STAC3 STMN1 STX1A SUB1 SUDS3 SUGT1 SUPT5H SUPT6H SURF6 TCF7L2 TCOF1 TFAP2A TH THAP1 THOC5 THRAP3 TMOD3 TMPO TNKS1BP1 TNP1 TOP1 TOP2A TP53 TP63 TP73 TSPY1 UBAC1 UBE2D3 UBE2R2 UBTF USP24 USP48 USP7 UTP14A UTP18 VAMP4 VDR VHL VTN WAS WDR44 WDR55 WEE1 XK XKRY XRCC1 XRCC4 XRCC5 XRCC6 XRN2 YBX1 YWHAB YWHAQ ZC3H13 ZC3H15 ZC3H8 ZFC3H1 ZHX1 ZRANB2	229 interacting genes: AR ARRB1 ARRB2 ATF2 ATP1A1 BANP BCL2 BCL3 BCL6 BRAF C1QBP CACYBP CAD CALCOCO1 CAPN2 CASP8 CASP9 CAV1 CD19 CDC25C CDX2 CEBPB CEP55 CITED2 CMTM3 COPS6 CREBBP CRP CSNK2A1 CTSD CUEDC2 DAPK1 DUSP1 DUSP16 DUSP2 DUSP3 DUSP4 DUSP5 DUSP6 DUSP7 DUSP9 DYRK1B EGFR EGLN3 EIF4EBP1 ELK1 ELK4 ENAH EP300 EPOR ERF ESR1 ESR2 ETS1 FCGR2B FHL3 FOS FOXO3 FRS2 FRS3 GAB1 GAB2 GABRR1 GAPDH GATA1 GATA2 GATA4 GJA1 GMFB GNPTAB GORASP2 GRB10 GRB2 GSK3B HDAC4 HDAC6 HIF1A HNF4A HSF1 HSF4 HSP90AA1 ID2 IER3 IFI35 IFNAR1 IQGAP1 IRS1 ITGB6 JUN JUND KARS1 KDR KHDRBS1 KLF11 KRT8 KSR1 KSR2 LAMTOR3 LCK LIFR LIPE LRPAP1 MAFA MAP2K1 MAP2K2 MAP2K4 MAP2K6 MAP2K7 MAP3K1 MAP3K10 MAPK14 MAPK8 MAPKAPK5 MAPT MBP MCL1 METAP2 MITF MKNK1 MKNK2 MTIF3 MTPN MYB MYC NCOA1 NCOA3 NDE1 NEFH NEK2 NGFR NKX2-1 NOXA1 NR3C1 NR4A1 NR5A1 NRL NTRK3 NUP153 PAK1 PAK2 PAX5 PDE4D PEA15 PEBP1 PKM PLA2G4A PLAT PLCB1 PLK3 PPARA PPARG PPP1CA PPP1R9B PPP2CA PPP2R5B PPP2R5C PRDX6 PRKCD PRKCE PRKCZ PRPSAP1 PTPN1 PTPN5 PTPN7 PTPRC PTPRE PTPRH PTPRR PXN RAF1 RB1 REST RET RGS19 RNF216 RPS6KA1 RPS6KA2 RPS6KA3 RPS6KA4 RPS6KB1 RPTOR RXRA SCNN1G SH2D3C SHANK3 SHC1 SLC9A1 SMAD1 SMAD2 SMAD3 SMAD4 SNCA SNCG SORBS3 SOS1 SP1 SREBF1 SREBF2 STAT3 STAT5A STAT5B STYX SUPT20H TCF3 TFCP2 TGIF1 TH TIAL1 TNFRSF1A TNFRSF25 TNFSF11 TNIP1 TNIP2 TNKS2 TOB1 TOP2A TP53 TPR TSC2 TTN UBE3A UBR5 UBTF VAV1 VDR YBX1 YBX3 ZC3HC1 ZFP36
Entrez ID		1457	5594
HPRD ID		00277	01496
Ensembl ID		ENSG00000101266	ENSG00000100030
Uniprot IDs		P68400	P28482 Q1HBJ4 Q499G7
PDB IDs		1JWH 1NA7 1PJK 2PVR 2ZJW 3AMY 3AT2 3AT3 3AT4 3AXW 3BQC 3C13 3FWQ 3H30 3JUH 3MB6 3MB7 3NGA 3NSZ 3OWJ 3OWK 3OWL 3PE1 3PE2 3PE4 3Q04 3Q9W 3Q9X 3Q9Y 3Q9Z 3QA0 3R0T 3RPS 3TAX 3U4U 3U87 3U9C 3W8L 3WAR 3WIK 3WIL 3WOW 4DGL 4FBX 4GRB 4GUB 4GYW 4GYY 4GZ3 4IB5 4KWP 4MD7 4MD8 4MD9 4NH1 4RLL 4UB7 4UBA 5B0X 5CLP 5CQU 5CQW 5CS6 5CSH 5CSP 5CSV 5CT0 5CTP 5CU0 5CU2 5CU3 5CU4 5CU6 5CVF 5CVG 5CVH 5CX9 5H8B 5H8E 5H8G 5HGV 5KU8 5KWH 5M44 5M4C 5M4F 5M4I 5MMF 5MMR 5MO5 5MO6 5MO7 5MO8 5MOD 5MOE 5MOH 5MOT 5MOV 5MOW 5MP8 5MPJ 5N1V 5N9K 5N9L 5N9N 5NQC 5OMY 5ONI 5OQU 5ORH 5ORJ 5ORK 5OS7 5OS8 5OSL 5OSP 5OSR 5OSU 5OSZ 5OT5 5OT6 5OTD 5OTH 5OTI 5OTL 5OTO 5OTP 5OTQ 5OTR 5OTS 5OTY 5OTZ 5OUE 5OUL 5OUM 5OUU 5OWH 5OWL 5OYF 5T1H 5VIE 5VIF 5ZN0 5ZN1 5ZN2 5ZN3 5ZN4 5ZN5 6A1C 6EHK 6EHU 6EII 6FVF 6FVG 6GIH 6GMD 6HBN 6HME 6HNW 6HNY 6HOP 6HOQ 6HOR 6HOT 6HOU 6JWA 6Q38 6Q4Q	1PME 1TVO 1WZY 2OJG 2OJI 2OJJ 2Y9Q 3D42 3D44 3I5Z 3I60 3SA0 3TEI 3W55 4FMQ 4FUX 4FUY 4FV0 4FV1 4FV2 4FV3 4FV4 4FV5 4FV6 4FV7 4FV8 4FV9 4G6N 4G6O 4H3P 4H3Q 4IZ5 4IZ7 4IZA 4N0S 4NIF 4O6E 4QP1 4QP2 4QP3 4QP4 4QP6 4QP7 4QP8 4QP9 4QPA 4QTA 4QTE 4XJ0 4ZXT 4ZZM 4ZZN 4ZZO 5AX3 5BUE 5BUI 5BUJ 5BVD 5BVE 5BVF 5K4I 5LCJ 5LCK 5NGU 5NHF 5NHH 5NHJ 5NHL 5NHO 5NHP 5NHV 5V60 5V61 5V62 5WP1 6D5Y 6DMG 6G54 6G8X 6G91 6G92 6G93 6G97 6G9A 6G9D 6G9H 6G9J 6G9K 6G9M 6G9N 6GDM 6GDQ 6GE0 6GJB 6GJD 6NBS 6OPG 6OPH 6OPI 6Q7K 6Q7S 6Q7T 6QA1 6QA3 6QA4 6QAG 6QAH 6QAL 6QAQ 6QAW 6SLG
Enriched GO Terms of Interacting Partners?
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