GATA5 and KLF2

Number of citations of the paper that reports this interaction (PubMedID 11375995)
21

Data Source:
BioGRID (two hybrid)

		GATA5	KLF2
Description		GATA binding protein 5	Kruppel like factor 2
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Nucleoplasm	Nuclear Chromatin Nucleus
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Zinc Ion Binding Transcription Regulatory Region DNA Binding	DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Protein Binding Metal Ion Binding
	Biological Process	Aortic Valve Morphogenesis Endocardial Cushion Fusion Blood Coagulation Negative Regulation Of Cardiac Muscle Hypertrophy Positive Regulation Of Gene Expression Negative Regulation Of Gene Expression Positive Regulation Of Notch Signaling Pathway Involved In Heart Induction Cell Fate Commitment Positive Regulation Of Transcription By RNA Polymerase II Cardiac Muscle Tissue Development Intestinal Epithelial Cell Differentiation Positive Regulation Of Cardiac Endothelial To Mesenchymal Transition Cellular Response To BMP Stimulus Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Heart Development	Negative Regulation Of Transcription By RNA Polymerase II Cell Morphogenesis In Utero Embryonic Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Interleukin-6 Production Multicellular Organism Growth Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Stress Regulation Of Gene Expression, Epigenetic Erythrocyte Maturation Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Retinoic Acid Receptor Signaling Pathway Positive Regulation Of Protein Metabolic Process Type I Pneumocyte Differentiation Cellular Response To Hydrogen Peroxide Cellular Response To Interleukin-1 Cellular Response To Tumor Necrosis Factor Cellular Response To Cycloheximide Cellular Response To Fluid Shear Stress Cellular Response To Laminar Fluid Shear Stress Cellular Stress Response To Acid Chemical Cellular Response To Peptide Negative Regulation Of Sprouting Angiogenesis
Pathways		Factors involved in megakaryocyte development and platelet production
Drugs
Diseases
GWAS		Benign prostatic hyperplasia and lower urinary tract symptoms ( 30410027) Central serous retinopathy ( 31872073) Chronic central serous retinopathy ( 30073298) Prostate cancer ( 23535732)	Depression in smokers ( 30219690) Diastolic blood pressure ( 30224653) Heel bone mineral density ( 30598549) Lymphocyte counts ( 27863252) Lymphocyte percentage of white cells ( 27863252)
Interacting Genes		3 interacting genes: EP300 HNF1A KLF2	7 interacting genes: EP300 GATA5 GATA6 GSK3B KAT2B PSME3 WWP1
Entrez ID		140628	10365
HPRD ID		17029	03602
Ensembl ID		ENSG00000130700	ENSG00000127528
Uniprot IDs		Q9BWX5	Q9Y5W3
PDB IDs
Enriched GO Terms of Interacting Partners?
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