CRP and FCGR2A

Number of citations of the paper that reports this interaction (PubMedID 10675363)
39

Data Source:
HPRD (in vivo)

		CRP	FCGR2A
Description		C-reactive protein	Fc fragment of IgG receptor IIa
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Golgi Apparatus Plasma Membrane Integral Component Of Membrane Secretory Granule Membrane
	Molecular Function	Complement Component C1q Binding Calcium Ion Binding Protein Binding Low-density Lipoprotein Particle Binding Choline Binding Identical Protein Binding Virion Binding Low-density Lipoprotein Particle Receptor Binding	Protein Binding IgG Binding
	Biological Process	Acute-phase Response Inflammatory Response Complement Activation, Classical Pathway Opsonization Positive Regulation Of Gene Expression Negative Regulation Of Macrophage Derived Foam Cell Differentiation Negative Regulation Of Lipid Storage Positive Regulation Of Superoxide Anion Generation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation By Host Of Viral Process Innate Immune Response Defense Response To Gram-positive Bacterium Negative Regulation Of Blood Vessel Diameter Regulation Of Interleukin-8 Secretion	Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation
Pathways		Classical antibody-mediated complement activation	FCGR activation FCGR activation Regulation of actin dynamics for phagocytic cup formation Role of phospholipids in phagocytosis Neutrophil degranulation FCGR3A-mediated IL10 synthesis
Drugs		N,N,N-Trimethyl-2-(phosphonooxy)ethanaminium CRx-139	Cetuximab Etanercept Immune Globulin Human Adalimumab Abciximab Gemtuzumab ozogamicin Trastuzumab Rituximab Basiliximab Muromonab Ibritumomab tiuxetan Tositumomab Alemtuzumab Alefacept Efalizumab Natalizumab Palivizumab Daclizumab Bevacizumab Sarilumab
Diseases		Systemic lupus erythematosus	Systemic lupus erythematosus
GWAS		Blood protein levels ( 30072576 29875488 23696881) C-reactive protein ( 22492993 19567438 21647738 18439548 18439552 21196492 23844046 22939635) C-reactive protein levels ( 24763700 29403010 30388399 21300955 28548082) C-reactive protein levels in ischemic stroke ( 26718567) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Inflammatory biomarkers ( 22291609) Inflammatory biomarkers in Kawasaki disease ( 25266886) Lung cancer ( 18385676) Metabolic traits ( 19060910) Protein quantitative trait loci ( 18464913) Select biomarker traits ( 17903293)	Ankylosing spondylitis ( 23749187) Blood protein levels ( 30072576 29875488 28240269) Chronic inflammatory diseases (ankylosing spondylitis, Crohn's disease, psoriasis, primary sclerosing cholangitis, ulcerative colitis) (pleiotropy) ( 26974007) Functional impairment in major depressive disorder, bipolar disorder and schizophrenia ( 24039173) Helicobacter pylori serologic status ( 23652523) Hematocrit ( 27863252) Inflammatory bowel disease ( 28067908 23128233) Kawasaki disease ( 28886140 22081228) Lipid metabolism phenotypes ( 22286219) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Rheumatoid arthritis ( 30423114 24390342) Rheumatoid arthritis (ACPA-positive) ( 24532676) Systemic lupus erythematosus ( 27399966 24871463 26663301 26502338 28714469) Takayasu arteritis ( 23830517) Ulcerative colitis ( 19915573 28067908 20228799 21297633)
Interacting Genes		21 interacting genes: APCS C1QA CFH ESS2 FCGR1A FCGR2A FCGR2B FN1 GLUD1 GMPPA GP6 H1-1 H2AC16 H2AC20 LAMC3 LEP MAPK1 MAPK3 MAPK8IP2 RPL13A SNRNP70	14 interacting genes: BLK CRP CRYAB FYN GP6 GRB2 HCK LAT LGALS3 LYN PIK3R1 SHC1 SYK UBQLN1
Entrez ID		1401	2212
HPRD ID		00422	00906
Ensembl ID		ENSG00000132693	ENSG00000143226
Uniprot IDs		P02741	P12318
PDB IDs		1B09 1CRV 1GNH 1LJ7 3L2Y 3PVN 3PVO	1FCG 1H9V 3D5O 3RY4 3RY5 3RY6
Enriched GO Terms of Interacting Partners?
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