GAB3 and GRAP2

Number of citations of the paper that reports this interaction (PubMedID 12773374)
45

Data Source:
HPRD (in vitro)

		GAB3	GRAP2
Description		GRB2 associated binding protein 3	GRB2 related adaptor protein 2
Image		No pdb structure
GO Annotations	Cellular Component		Nucleus Nucleoplasm Cytoplasm Endosome Cytosol Plasma Membrane
	Molecular Function		SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Macrophage Differentiation	Ras Protein Signal Transduction Cell-cell Signaling Positive Regulation Of Signal Transduction T Cell Costimulation Fc-epsilon Receptor Signaling Pathway T Cell Receptor Signaling Pathway
Pathways			Signaling by SCF-KIT Generation of second messenger molecules DAP12 signaling FCERI mediated MAPK activation FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization CD28 co-stimulation
Drugs
Diseases
GWAS		Iron status biomarkers (transferrin saturation) ( 28334935) Mean corpuscular hemoglobin ( 28453575)	Body mass index ( 26426971) Systemic lupus erythematosus ( 28714469)
Interacting Genes		8 interacting genes: CSF1 FYN GRAP2 GRB2 LYN PIK3R1 PTPN11 SRC	66 interacting genes: BAG4 BEND5 BLNK CBL CBLB CBY2 CCHCR1 CCNDBP1 CD28 COG6 CSF1R DNM2 DVL2 EGFR ETV5 FASLG GAB1 GAB2 GAB3 GAREM1 GATA1 GFAP GOLGA2 GRB2 HNRNPK IHO1 IKZF3 KHDRBS1 KHDRBS2 KIT KRT13 KRTAP1-3 KRTAP4-11 KRTAP4-12 LAT LATS2 LAX1 LCP2 LNX1 LNX2 MAGED1 MAP4K1 MKRN3 MTUS2 PNMA1 PRPH2 RACK1 RBPMS RBX1 RIN3 RINT1 SHB SHC1 SOS2 SPRY2 SSX2IP STAMBP TFIP11 TLE5 TRAF1 TSNAXIP1 USP8 WWP2 YWHAE ZBTB7B ZNF526
Entrez ID		139716	9402
HPRD ID		06571	05156
Ensembl ID		ENSG00000160219	ENSG00000100351
Uniprot IDs		Q8WWW8	B7Z8E3 O75791 Q6FI14
PDB IDs			5GJH
Enriched GO Terms of Interacting Partners?
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