ATF6B and XBP1

Number of citations of the paper that reports this interaction (PubMedID 23661758)
49

Data Source:
BioGRID (fluorescent resonance energy transfer)

		ATF6B	XBP1
Description		activating transcription factor 6 beta	X-box binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nuclear Chromatin Nucleus Endoplasmic Reticulum Membrane Golgi Apparatus Integral Component Of Endoplasmic Reticulum Membrane Protein-DNA Complex RNA Polymerase II Transcription Factor Complex	Cell Nucleus Nucleoplasm Cytoplasm Endoplasmic Reticulum Integral Component Of Endoplasmic Reticulum Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Activator Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Protein Binding CAMP Response Element Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific Proximal Promoter Sequence-specific DNA Binding DNA Binding DNA-binding Transcription Factor Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	Transcription, DNA-templated Signal Transduction ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription By RNA Polymerase II Negative Regulation Of ATF6-mediated Unfolded Protein Response Positive Regulation Of Transcription From RNA Polymerase II Promoter In Response To Endoplasmic Reticulum Stress	Angiogenesis Liver Development Endothelial Cell Proliferation Positive Regulation Of Immunoglobulin Production Transcription By RNA Polymerase II Ubiquitin-dependent Protein Catabolic Process Fatty Acid Biosynthetic Process Autophagy Immune Response Positive Regulation Of Transcription From RNA Polymerase II Promoter Involved In Unfolded Protein Response Muscle Organ Development Positive Regulation Of Cell Proliferation Regulation Of Autophagy Negative Regulation Of Myotube Differentiation Protein Transport Positive Regulation Of Cell Migration Endoplasmic Reticulum Unfolded Protein Response Exocrine Pancreas Development Protein Destabilization Cellular Response To Nutrient Cellular Response To Insulin Stimulus Cellular Triglyceride Homeostasis Positive Regulation Of Vascular Wound Healing IRE1-mediated Unfolded Protein Response ATF6-mediated Unfolded Protein Response Cellular Response To Glucose Starvation Cholesterol Homeostasis Negative Regulation Of Apoptotic Process Positive Regulation Of MHC Class II Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of T Cell Differentiation Positive Regulation Of Fat Cell Differentiation Positive Regulation Of Angiogenesis Positive Regulation Of Transcription By RNA Polymerase II Neuron Development Positive Regulation Of Immunoglobulin Secretion Fatty Acid Homeostasis Sterol Homeostasis Adipose Tissue Development Epithelial Cell Maturation Involved In Salivary Gland Development Intrinsic Apoptotic Signaling Pathway In Response To Endoplasmic Reticulum Stress Cellular Response To Lipopolysaccharide Cellular Response To Amino Acid Stimulus Cellular Response To Fructose Stimulus Cellular Response To Glucose Stimulus Cellular Response To Interleukin-4 Cellular Response To Peptide Hormone Stimulus Positive Regulation Of Plasma Cell Differentiation Positive Regulation Of Endoplasmic Reticulum Unfolded Protein Response Negative Regulation Of Endoplasmic Reticulum Stress-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of Lactation Response To Insulin-like Growth Factor Stimulus Cellular Response To Leukemia Inhibitory Factor Positive Regulation Of Hepatocyte Proliferation Positive Regulation Of Interleukin-6 Secretion
Pathways
Drugs
Diseases
GWAS		Age-related macular degeneration ( 23577725) Autism spectrum disorder or schizophrenia ( 28540026) Automobile speeding propensity ( 30643258) Blood protein levels ( 30072576 29875488 28240269) Blood protein levels in cardiovascular risk ( 28369058) Inflammatory bowel disease ( 28067908) Intraocular pressure ( 29617998) Mean corpuscular volume ( 27863252) Prostate cancer ( 23535732) Takayasu arteritis ( 25604533) Ulcerative colitis ( 28067908)	Esophageal cancer (squamous cell) ( 22960999) Esophageal squamous cell carcinoma ( 25129146) Heel bone mineral density ( 28869591) Mean arterial pressure ( 29403010) Pancreatic cancer ( 25086665)
Interacting Genes		9 interacting genes: ATF6 CDK6 CREBZF MBTPS1 MBTPS2 NFYA NFYC PHOX2A XBP1	21 interacting genes: ATF6 ATF6B CREBZF ESR1 FOS FUBP3 GLI1 H1-0 H1-10 HDGF MDM2 MTNR1B NR0B2 PCBD2 RBL2 SRSF1 SSX4 TRIP4 UBE2I ZNF440 ZNF580
Entrez ID		1388	7494
HPRD ID		02992	01908
Ensembl ID		ENSG00000213676	ENSG00000100219
Uniprot IDs		A0A1U9X796 Q6AZW6 Q99941	A0A024R1F0 P17861
PDB IDs			6R5Q 6R6G 6R6P 6R7Q
Enriched GO Terms of Interacting Partners?
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