CPOX and UBE2G2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CPOX	UBE2G2
Description		coproporphyrinogen oxidase	ubiquitin conjugating enzyme E2 G2
Image
GO Annotations	Cellular Component	Cytoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Intermembrane Space Cytosol	Endoplasmic Reticulum Cytosol
	Molecular Function	Coproporphyrinogen Oxidase Activity Structural Constituent Of Eye Lens Protein Homodimerization Activity	Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Identical Protein Binding Ubiquitin Conjugating Enzyme Activity
	Biological Process	Protoporphyrinogen IX Biosynthetic Process Heme Biosynthetic Process Response To Iron Ion Response To Lead Ion Response To Insecticide Response To Arsenic-containing Substance Response To Methylmercury Oxidation-reduction Process	Protein Polyubiquitination Ubiquitin-dependent Protein Catabolic Process Protein Ubiquitination Ubiquitin-dependent ERAD Pathway Cellular Response To Interferon-beta Cellular Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Retrograde Protein Transport, ER To Cytosol
Pathways		Heme biosynthesis	Synthesis of active ubiquitin: roles of E1 and E2 enzymes Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Hepatic porphyria, including: Porphyria Cutanea Tarda (PCT); VHepatoerythropoietic porphyria; Acute Intermittent Porphyria (AIP); Variegate porphyria (VP); ALA-dehydratase deficiency porphyria (ALADP); Hereditary Coproporphyria (HCP)
GWAS
Interacting Genes		2 interacting genes: REEP5 UBE2G2	38 interacting genes: AMFR ARL14 BIRC8 CBL CNNM3 CPOX CUL9 ECPAS FARP2 HBS1L KDM2A MDM2 MGRN1 MLLT6 MUL1 NDUFS4 POLR3F PRKN RBX1 RC3H1 RC3H2 RFFL RNF111 RNF146 RNF157 RNF168 RNF26 RNF5 TMEM45B TRIM3 TRIM43 UBA1 UBA6 UBC UBE2J2 UBE3A VAMP8 ZNRF4
Entrez ID		1371	7327
HPRD ID		00417	04387
Ensembl ID		ENSG00000080819	ENSG00000184787
Uniprot IDs		P36551	P60604
PDB IDs		2AEX	2CYX 2KLY 2LXP 3H8K 4LAD
Enriched GO Terms of Interacting Partners?
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