CPN1 and C5

Number of citations of the paper that reports this interaction (PubMedID 11939578)
39

Data Source:
HPRD (in vitro)

		CPN1	C5
Description		carboxypeptidase N subunit 1	complement C5
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Region Membrane Attack Complex Extracellular Space Extracellular Exosome
	Molecular Function	Metallocarboxypeptidase Activity Zinc Ion Binding	Endopeptidase Inhibitor Activity Signaling Receptor Binding Protein Binding Chemokine Activity
	Biological Process	Peptide Metabolic Process Bradykinin Catabolic Process Protein Processing Regulation Of Complement Activation Response To Glucocorticoid	Activation Of MAPK Activity Chemotaxis Inflammatory Response Complement Activation, Alternative Pathway Complement Activation, Classical Pathway Cell Surface Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Vascular Endothelial Growth Factor Production Negative Regulation Of Macrophage Chemotaxis Negative Regulation Of Endopeptidase Activity Cytolysis Regulation Of Complement Activation Cell Chemotaxis Positive Regulation Of Chemokine Secretion
Pathways		Regulation of Complement cascade	Terminal pathway of complement Activation of C3 and C5 Peptide ligand-binding receptors G alpha (i) signalling events Regulation of Complement cascade
Drugs		Zinc	Immune Globulin Human Eculizumab Zinc Copper
Diseases			Late complement pathway defects, including the following seven diseases: C5 deficiency; C6 deficiency; C7 deficiency; C8 alpha-chain deficiency; C8 beta-chain deficiency; C8 gamma-chain deficiency; C9 deficiency
GWAS		Blood protein levels ( 29875488 28240269 23696881) Creatine kinase levels ( 29403010) Dermatomyositis ( 27153935) Femoral neck bone mineral density ( 22504420) General cognitive ability ( 29844566) Heel bone mineral density ( 30598549) Height ( 20881960) Liver enzyme levels ( 18940312) Liver enzyme levels (alanine transaminase) ( 22001757)	Blood protein levels ( 30072576) Coronary artery disease ( 29212778) Hip circumference adjusted for BMI ( 25673412) Pulse pressure ( 27841878) Rheumatoid arthritis ( 30891314 24390342 20453842 19503088)
Interacting Genes		7 interacting genes: C3 C5 CDC42 CLEC4G CPN2 KNG1 STC2	10 interacting genes: C2 C3 C5AR1 C6 C7 C8B CPB2 CPN1 CREB3L1 LMNA
Entrez ID		1369	727
HPRD ID		09120	00405
Ensembl ID		ENSG00000120054	ENSG00000106804
Uniprot IDs		P15169	P01031 Q59GS8
PDB IDs		2NSM	1CFA 1KJS 1XWE 3CU7 3HQA 3HQB 3KLS 3KM9 3PRX 3PVM 4A5W 4E0S 4P39 4UU9 5B4P 5B71 5HCC 5HCD 5HCE 5I5K 6H03 6H04
Enriched GO Terms of Interacting Partners?
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