COX6A2 and COL6A2

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		COX6A2	COL6A2
Description		cytochrome c oxidase subunit 6A2	collagen type VI alpha 2 chain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrial Respiratory Chain Complex IV	Extracellular Region Collagen Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Protein-containing Complex Sarcolemma Collagen-containing Extracellular Matrix Extracellular Exosome Extracellular Vesicle
	Molecular Function	Cytochrome-c Oxidase Activity Enzyme Regulator Activity	Protein Binding Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength
	Biological Process	Generation Of Precursor Metabolites And Energy Mitochondrial Electron Transport, Cytochrome C To Oxygen Aerobic Respiration Regulation Of Catalytic Activity Proton Transmembrane Transport	Growth Plate Cartilage Chondrocyte Morphogenesis Cell Adhesion Response To Glucose Extracellular Matrix Organization
Pathways			Collagen degradation Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions ECM proteoglycans ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs		Cholic Acid N-Formylmethionine
Diseases			Congenital muscular dystrophies (CMD/MDC), including: Merosin-deficient CMD (MDC1A); Ullrich CMD (UCMD); Integrin alpha7-deficient CMD; CMD with joint hyperlaxity (CMDH); CMD with epidermolysis bullosa; Walker-Warburg syndrome (WWS); Muscle-eye-brain disease (MEB); Fukuyama CMD (FCMD); CMD with muscle hypertrophy (MDC1C); CMD with severe intellectual impairment and abnormal glycosylation (MDC1D); Rigid spine syndrome (RSS); LMNA-deficient CMD; CMD with respiratory failure and muscle hypertrophy (MDC1B); Bethlem myopathy
GWAS			Central corneal thickness ( 29760442) Height ( 31562340) Intraocular pressure ( 29235454)
Interacting Genes		5 interacting genes: APP COL6A2 MRPL12 POT1 SNX21	6 interacting genes: ABCD3 COL6A1 COX6A2 FN1 SIRPA SLC38A3
Entrez ID		1339	1292
HPRD ID		03598	02110
Ensembl ID		ENSG00000156885	ENSG00000142173
Uniprot IDs		Q02221	A0A384MDP3 P12110
PDB IDs
Enriched GO Terms of Interacting Partners?
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