AP1S3 and PRKAG1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		AP1S3	PRKAG1
Description		adaptor related protein complex 1 subunit sigma 3	protein kinase AMP-activated non-catalytic subunit gamma 1
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GO Annotations	Cellular Component	Golgi Membrane Lysosomal Membrane Cytosol Clathrin-coated Pit Membrane Coat Cytoplasmic Vesicle Membrane Trans-Golgi Network Membrane Intracellular Membrane-bounded Organelle	Nucleoplasm Cytosol Membrane Nucleotide-activated Protein Kinase Complex
	Molecular Function	Protein Binding	Protein Kinase Activity CAMP-dependent Protein Kinase Activity Protein Binding ATP Binding CAMP-dependent Protein Kinase Regulator Activity AMP Binding Protein Kinase Regulator Activity Protein Kinase Binding ADP Binding
	Biological Process	Protein Targeting Vesicle-mediated Transport Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Defense Response To Virus By Virus	Regulation Of Glycolytic Process Protein Phosphorylation Fatty Acid Biosynthetic Process Cell Cycle Arrest Signal Transduction Spermatogenesis Positive Regulation Of Gene Expression Macroautophagy Regulation Of Macroautophagy Positive Regulation Of Protein Kinase Activity Import Into Nucleus Regulation Of Signal Transduction By P53 Class Mediator Regulation Of CAMP-dependent Protein Kinase Activity
Pathways		Nef mediated downregulation of MHC class I complex cell surface expression MHC class II antigen presentation Lysosome Vesicle Biogenesis Golgi Associated Vesicle Biogenesis	Translocation of SLC2A4 (GLUT4) to the plasma membrane Macroautophagy Activation of PPARGC1A (PGC-1alpha) by phosphorylation Energy dependent regulation of mTOR by LKB1-AMPK TP53 Regulates Metabolic Genes Regulation of TP53 Activity through Phosphorylation Lipophagy Activation of AMPK downstream of NMDARs
Drugs			Acetylsalicylic acid
Diseases
GWAS		Airway wall thickness ( 25517131) Asthma ( 30929738) Asthma (childhood onset) ( 30929738) Initial alcohol sensitivity ( 30276832) Night sleep phenotypes ( 27126917) Sodium levels ( 29403010)	Bipolar disorder ( 31043756) Body mass index ( 29273807) HDL cholesterol ( 30275531) Pulse pressure ( 27618447) Systolic blood pressure ( 27618447 30578418)
Interacting Genes		2 interacting genes: AAGAB PRKAG1	16 interacting genes: ACACA AP1S3 C1orf94 CBS EIF3G KCNN4 KEAP1 KRTAP10-3 KRTAP4-2 PAICS PRKAA1 PRKAA2 PRKAB1 PRKAB2 PRKAG2 TEKT1
Entrez ID		130340	5571
HPRD ID		16495	04118
Ensembl ID		ENSG00000152056	ENSG00000181929
Uniprot IDs		Q96PC3	A0A024R125 P54619
PDB IDs		4HMY 6CM9 6CRI 6D83 6D84 6DFF	2UV4 2UV5 2UV6 2UV7 4CFE 4CFF 4RER 4REW 4ZHX 5EZV 5ISO 6B1U 6B2E 6C9F 6C9G 6C9H 6C9J
Enriched GO Terms of Interacting Partners?
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