COL8A1 and ADAMTSL4

Number of citations of the paper that reports this interaction (PubMedID 19060904)
283

Data Source:
BioGRID (two hybrid)

		COL8A1	ADAMTSL4
Description		collagen type VIII alpha 1 chain	ADAMTS like 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type VIII Trimer Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Interstitial Matrix Endoplasmic Reticulum Lumen Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength	Protease Binding Protein Binding Peptidase Activity
	Biological Process	Angiogenesis Cell Adhesion Positive Regulation Of Cell-substrate Adhesion Extracellular Matrix Organization Endodermal Cell Differentiation Camera-type Eye Morphogenesis Epithelial Cell Proliferation	Epithelial Cell Development Proteolysis Apoptotic Process Extracellular Matrix Organization Positive Regulation Of Apoptotic Process
Pathways		Collagen degradation Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Collagen chain trimerization	Defective B3GALTL causes Peters-plus syndrome (PpS) O-glycosylation of TSR domain-containing proteins
Drugs
Diseases			Ectopia lentis
GWAS		Advanced age-related macular degeneration ( 26691988) Age-related macular degeneration ( 20385826 23455636) Axial length ( 24144296) Childhood ear infection ( 27182965) Cleft lip with or without cleft palate ( 28054174) Nonsyndromic cleft lip with cleft palate ( 28232668) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 31798171 28073927) Superior frontal gyrus grey matter volume ( 25335168) Vertical cup-disc ratio ( 31798171 25241763 28073927)	Coronary artery disease ( 29212778) Migraine ( 27322543) Rhegmatogenous retinal detachment ( 23585552)
Interacting Genes		20 interacting genes: ADAMTSL4 COL8A2 CREB5 EFEMP2 INCA1 ITGA1 ITGA2 KLHL12 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP26-1 KRTAP4-12 KRTAP9-2 NOTCH2NLA REL SP4 UBQLN4 VAC14	110 interacting genes: ADAMTSL5 AMMECR1 APOL6 AQP1 ARNT2 ASPSCR1 CATSPER1 CCDC26 CFAP206 CHCHD2 CHRNG CLEC18A COL8A1 CPNE7 CREB5 CST2 CTSB CXCL16 CYP2S1 DGCR6 DIP2A DLK2 DNPEP DSCR8 EIF4E2 FAH FAM124B FARS2 FBLN1 FBXW5 FHL3 FKBP1B FLNA FRS3 GATA2 GIP GLRX3 GMCL2 GNE GNMT GOLGA8EP HGF HNRNPLL HOXA1 KIF1A KRTAP10-1 KRTAP10-11 KRTAP10-3 KRTAP10-5 KRTAP10-8 KRTAP10-9 KRTAP4-11 KRTAP4-12 KRTAP4-2 KRTAP5-6 KRTAP5-9 KRTAP9-2 KRTAP9-4 LCE1B LCE2D LCE3C LCE3E LCE4A LGALS14 LHX4 LINC00671 LMO1 LMO2 LONRF1 LRRC29 MAPKBP1 MID2 MORN3 MVP NATD1 NMUR2 NTF4 NTN4 OLFM3 OTX1 PID1 PIN1 PLSCR1 PRKAB2 PTGER3 RAB2B RCHY1 RHOJ SALL2 SHFL SLC23A1 SLC6A20 SMARCC1 SORBS3 SPATA8 SPINK2 SPRY2 STK16 SUSD6 TAPBPL TCEA2 TMEM150A TMSB4XP6 TOP3B TRIM42 TRIP6 TSSK3 TUBGCP4 ZNF417 ZNF587
Entrez ID		1295	54507
HPRD ID		00372	18237
Ensembl ID		ENSG00000144810	ENSG00000143382
Uniprot IDs		P27658	B7ZMJ3 Q6UY14 Q9UFG7
PDB IDs
Enriched GO Terms of Interacting Partners?
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