COL4A4 and MATN2

Number of citations of the paper that reports this interaction (PubMedID 12180907)
12

Data Source:
HPRD (in vivo)

		COL4A4	MATN2
Description		collagen type IV alpha 4 chain	matrilin 2
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Type IV Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Collagen-containing Extracellular Matrix	Basement Membrane Extracellular Space Extracellular Matrix Collagen-containing Extracellular Matrix
	Molecular Function	Extracellular Matrix Structural Constituent Extracellular Matrix Structural Constituent Conferring Tensile Strength	Extracellular Matrix Structural Constituent Calcium Ion Binding Protein Binding
	Biological Process	Extracellular Matrix Organization Glomerular Basement Membrane Development Collagen-activated Tyrosine Kinase Receptor Signaling Pathway	Neuron Migration Growth Plate Cartilage Chondrocyte Morphogenesis Axon Guidance Biological_process Glial Cell Migration Dendrite Regeneration Response To Axon Injury
Pathways		Collagen degradation Collagen degradation Extracellular matrix organization Collagen biosynthesis and modifying enzymes Signaling by PDGF Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Integrin cell surface interactions Anchoring fibril formation Crosslinking of collagen fibrils Laminin interactions Laminin interactions Non-integrin membrane-ECM interactions ECM proteoglycans NCAM1 interactions Collagen chain trimerization
Drugs
Diseases		Benign familial hematuria; Thin basement membrane nephropathy Alport syndrome
GWAS		Birth weight ( 31043758) Body mass index ( 28270201 25673413) Coronary artery disease ( 29212778) Immune reponse to smallpox (secreted IFN-alpha) ( 22610502) Macular thickness ( 30535121) Systolic blood pressure ( 30578418) Urinary albumin excretion ( 30220432) Urinary albumin excretion (no hypertensive medication) ( 30220432) Urinary albumin-to-creatinine ratio ( 31630189 31511532)	Adverse response to chemotherapy (neutropenia/leucopenia) (paclitaxel) ( 23648065) Diffusing capacity of carbon monoxide ( 30694715) Erectile dysfunction ( 30583798)
Interacting Genes		13 interacting genes: ANTXR2 CD93 DCN FBLN2 FN1 HABP2 MATN2 MMP9 MTDH OSM SAA1 SERPINE2 TGFBI	17 interacting genes: ATXN1 ATXN1L ATXN7 CACNA1A CBFA2T3 COL1A1 COL4A1 COL4A2 COL4A3 COL4A4 COL4A5 COL4A6 DVL3 FBN2 FN1 MATN1 MATN4
Entrez ID		1286	4147
HPRD ID		00360	03660
Ensembl ID		ENSG00000081052	ENSG00000132561
Uniprot IDs		P53420	A0A140VKH7 O00339 Q8N2G3
PDB IDs		5NB1
Enriched GO Terms of Interacting Partners?
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