ADH1B and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ADH1B	SERPINA3
Description		alcohol dehydrogenase 1B (class I), beta polypeptide	serpin family A member 3
Image
GO Annotations	Cellular Component	Nucleoplasm Cytosol Plasma Membrane	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	Alcohol Dehydrogenase Activity, Zinc-dependent Retinol Dehydrogenase Activity Zinc Ion Binding	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Retinoid Metabolic Process Ethanol Oxidation Retinol Metabolic Process Retinoic Acid Metabolic Process	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation
Pathways		Ethanol oxidation	Platelet degranulation Neutrophil degranulation
Drugs		NADH Fomepizole N-Benzylformamide 4-Iodopyrazole 2'-Monophosphoadenosine 5'-Diphosphoribose Cyclohexanol N-Heptylformamide Glycerin	Zinc
Diseases
GWAS		Alcohol consumption ( 23743675 28937693 31358974) Alcohol consumption (drinkers vs non-drinkers) ( 28485404) Alcohol consumption (drinks per week) ( 28485404 30643258 30679032) Alcohol consumption in current drinkers ( 28937693) Alcohol dependence ( 24166409 23456092 28714907 31591379 31090166 22004471) Alcohol dependence (desire to cut drinking) ( 31090166) Alcohol dependence (tolerance) ( 31090166) Alcohol dependence symptom count ( 31090166) Alcohol use disorder ( 30940813) Alcohol use disorder (consumption score) ( 30940813 30336701) Alcohol use disorder (dependence and problematic use scores) ( 30336701) Bitter alcoholic beverage consumption ( 31046077) Blood urea nitrogen levels ( 31152163) Esophageal cancer ( 19698717) Esophageal cancer (alcohol interaction) ( 22960999) Heel bone mineral density ( 30598549) Initial pursuit acceleration ( 29064472) Lung cancer ( 28604730) Maximum habitual alcohol consumption ( 31151762) Metabolite levels ( 23823483) Oral cavity and pharyngeal cancer ( 21437268 27749845) Oral cavity cancer ( 27749845) Oropharynx cancer ( 27749845) Regular attendance at a pub or social club ( 29970889) Risk-taking tendency (4-domain principal component model) ( 30643258) Urinary sodium excretion ( 31409800)	Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)
Interacting Genes		5 interacting genes: IRAK3 PDE4DIP PML RACK1 SERPINA3	26 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		125	12
HPRD ID		00065	00120
Ensembl ID		ENSG00000196616	ENSG00000196136
Uniprot IDs		D6RHZ6 P00325 V9HW50	A0A024R6P0 P01011
PDB IDs		1DEH 1HDX 1HDY 1HDZ 1HSZ 1HTB 1U3U 1U3V 3HUD	1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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