SPACA3 and ZP3

Number of citations of the paper that reports this interaction (PubMedID 19945174)
10

Data Source:
BioGRID (two hybrid)

		SPACA3	ZP3
Description		sperm acrosome associated 3	zona pellucida glycoprotein 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Acrosomal Membrane Extracellular Region Integral Component Of Membrane Secretory Granule Acrosomal Matrix	Extracellular Region Extracellular Space Plasma Membrane Integral Component Of Membrane Extracellular Matrix Egg Coat Collagen-containing Extracellular Matrix
	Molecular Function	Lysozyme Activity Protein Binding	Extracellular Matrix Structural Constituent Protein Binding Carbohydrate Binding Acrosin Binding Structural Constituent Of Egg Coat Identical Protein Binding Receptor Ligand Activity
	Biological Process	Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Sperm-egg Recognition Monocyte Activation Positive Regulation Of Macrophage Activation Positive Regulation Of Phagocytosis Defense Response To Gram-negative Bacterium Defense Response To Gram-positive Bacterium	Positive Regulation Of Type IV Hypersensitivity Blastocyst Formation Humoral Immune Response Mediated By Circulating Immunoglobulin Positive Regulation Of Leukocyte Migration Positive Regulation Of Humoral Immune Response Binding Of Sperm To Zona Pellucida Positive Regulation Of Phosphatidylinositol Biosynthetic Process Positive Regulation Of Interferon-gamma Production Positive Regulation Of Interleukin-4 Production Egg Coat Formation Positive Regulation Of T Cell Proliferation Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Phosphatidylinositol-mediated Signaling Oocyte Development Positive Regulation Of Inflammatory Response Positive Regulation Of Acrosome Reaction Negative Regulation Of Binding Of Sperm To Zona Pellucida Positive Regulation Of Acrosomal Vesicle Exocytosis Positive Regulation Of Ovarian Follicle Development Positive Regulation Of Antral Ovarian Follicle Growth
Pathways			Interaction With Cumulus Cells And The Zona Pellucida
Drugs
Diseases
GWAS		Plasma anti-thyroid peroxidase levels ( 29678681) Thyroxine levels ( 30843173)	Parkinson disease and lewy body pathology ( 25663231)
Interacting Genes		1 interacting genes: ZP3	9 interacting genes: ACR ENGASE FURIN MICALL1 MRPS16 OR2L13 PCDH17 SPACA3 UBAP2L
Entrez ID		124912	7784
HPRD ID		15420	01690
Ensembl ID		ENSG00000141316	ENSG00000188372
Uniprot IDs		A0A080YUZ7 E9PF91 Q05C28 Q8IXA5	P21754
PDB IDs
Enriched GO Terms of Interacting Partners?
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