ABCC2 and TUBB3

Number of citations of the paper that reports this interaction (PubMedID 21059598)
6

Data Source:
BioGRID (pull down)

		ABCC2	TUBB3
Description		ATP binding cassette subfamily C member 2	tubulin beta 3 class III
Image		No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane Cell Surface Membrane Apical Plasma Membrane Brush Border Membrane Intercellular Canaliculus	Nucleus Cytoplasm Microtubule Lamellipodium Filopodium Axon Dendrite Growth Cone Extracellular Exosome
	Molecular Function	Protein Binding ATP Binding Organic Anion Transmembrane Transporter Activity Xenobiotic Transmembrane Transporting ATPase Activity Bilirubin Transmembrane Transporter Activity ATPase Activity Protein Domain Specific Binding ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity	GTPase Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Netrin Receptor Binding
	Biological Process	Response To Oxidative Stress Female Pregnancy Response To Heat Negative Regulation Of Gene Expression Mercury Ion Transport Bile Acid And Bile Salt Transport Canalicular Bile Acid Transport Bilirubin Transport Prostaglandin Transport Cellular Chloride Ion Homeostasis Response To Methotrexate Response To Estradiol Response To Glucagon Xenobiotic Catabolic Process Response To Estrogen Response To Arsenic-containing Substance Transmembrane Transport Thyroid Hormone Transport Transepithelial Transport Cellular Response To Lipopolysaccharide Cellular Response To Interleukin-1 Cellular Response To Interleukin-6 Cellular Response To Tumor Necrosis Factor Cellular Response To Dexamethasone Stimulus Leukotriene Transport Benzylpenicillin Metabolic Process Drug Transmembrane Export Drug Transport Across Blood-brain Barrier	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Axon Guidance Neuron Differentiation Netrin-activated Signaling Pathway Dorsal Root Ganglion Development
Pathways		Heme degradation ABC-family proteins mediated transport Defective ABCC2 causes Dubin-Johnson syndrome	Translocation of SLC2A4 (GLUT4) to the plasma membrane Microtubule-dependent trafficking of connexons from Golgi to the plasma membrane Gap junction assembly MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion HSP90 chaperone cycle for steroid hormone receptors (SHR) Recruitment of NuMA to mitotic centrosomes Prefoldin mediated transfer of substrate to CCT/TriC Formation of tubulin folding intermediates by CCT/TriC Post-chaperonin tubulin folding pathway Recycling pathway of L1 Recycling pathway of L1 Hedgehog 'off' state Cilium Assembly Intraflagellar transport RHO GTPases activate IQGAPs RHO GTPases Activate Formins COPI-mediated anterograde transport COPI-dependent Golgi-to-ER retrograde traffic COPI-independent Golgi-to-ER retrograde traffic Mitotic Prometaphase The role of GTSE1 in G2/M progression after G2 checkpoint Carboxyterminal post-translational modifications of tubulin Carboxyterminal post-translational modifications of tubulin HCMV Early Events Assembly and cell surface presentation of NMDA receptors Activation of AMPK downstream of NMDARs Aggrephagy Aggrephagy EML4 and NUDC in mitotic spindle formation Sealing of the nuclear envelope (NE) by ESCRT-III Kinesins
Drugs		ATP Sulfinpyrazone	Epothilone D Patupilone Ixabepilone CYT997 ZEN-012 Phenethyl Isothiocyanate
Diseases		Hyperbilirubinemia; Crigler-Najjar syndrome, type I (CN1); Crigler-Najjar syndrome, type II (CN2); Gilbert Syndrome; Dubin-Johnson syndrome (DJS)	Congenital fibrosis of the extraocular muscles (CFEOM)
GWAS		Carboplatin disposition in epthelial ovarian cancer ( 29367611) Colorectal cancer ( 26151821 24737748)	Obsessive-compulsive disorder or autism spectrum disorder ( 28641744) Red vs. brown/black hair color ( 30531825) Rosacea symptom severity ( 29771307) Squamous cell carcinoma ( 31174203)
Interacting Genes		12 interacting genes: AZIN1 CANX HSPA4 MCPH1 NFKB1 PDZD3 PDZK1 RDX SHANK3 SLC9A3R1 TUBB3 UBQLN1	31 interacting genes: ABCC2 ANXA7 ARHGEF7 CAMSAP3 CDKN1A DDX39B EEF1G GABARAP GZMK HEXD INSM1 KHDRBS1 LAPTM4A LIG1 MAP7D3 MAPT MRPL28 MTCL1 MTDH PHIP PLK1 RCC1 RILPL2 ROBO1 SEL1L3 SMN1 SPTSSA TERF1 TF TK1 TPTE
Entrez ID		1244	10381
HPRD ID		03065	04044
Ensembl ID		ENSG00000023839	ENSG00000258947
Uniprot IDs		Q92887	Q13509 Q53G92
PDB IDs			5IJ0 5IJ9 5JCO 6E7B 6S8L
Enriched GO Terms of Interacting Partners?
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