NRN1L and TREM2

Number of citations of the paper that reports this interaction (PubMedID 27477018)
134

Data Source:
BioGRID (pull down)

		NRN1L	TREM2
Description		neuritin 1 like	triggering receptor expressed on myeloid cells 2
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Plasma Membrane Axon Anchored Component Of Plasma Membrane	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Integral Component Of Membrane Intrinsic Component Of Plasma Membrane
	Molecular Function	Identical Protein Binding	Lipopolysaccharide Binding Amyloid-beta Binding Protein Binding Phospholipid Binding High-density Lipoprotein Particle Binding Lipid Binding Low-density Lipoprotein Particle Binding Apolipoprotein Binding Apolipoprotein A-I Binding Very-low-density Lipoprotein Particle Binding Signaling Receptor Activity Peptidoglycan Binding Protein-containing Complex Binding Lipoteichoic Acid Binding Lipoprotein Particle Binding Scaffold Protein Binding Protein Tyrosine Kinase Binding
	Biological Process	Neuron Projection Extension	Microglial Cell Activation Positive Regulation Of Protein Phosphorylation Microglial Cell Activation Involved In Immune Response Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Response To Ischemia Phagocytosis, Engulfment Humoral Immune Response Regulation Of Gene Expression Negative Regulation Of Autophagy Positive Regulation Of Gene Expression Positive Regulation Of Mitochondrion Organization Osteoclast Differentiation Regulation Of TOR Signaling Positive Regulation Of TOR Signaling Detection Of Lipopolysaccharide Detection Of Peptidoglycan Regulation Of Interleukin-6 Production Negative Regulation Of Interleukin-1 Beta Production Negative Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Interleukin-10 Production Positive Regulation Of Macrophage Fusion Defense Response To Bacterium Negative Regulation Of Apoptotic Process Apoptotic Cell Clearance Innate Immune Response Regulation Of Innate Immune Response Positive Regulation Of Osteoclast Differentiation Astrocyte Activation Positive Regulation Of Protein Secretion Regulation Of Peptidyl-tyrosine Phosphorylation Positive Regulation Of Peptidyl-tyrosine Phosphorylation Regulation Of Immune Response Positive Regulation Of Calcium-mediated Signaling Positive Regulation Of Chemotaxis Regulation Of Resting Membrane Potential Positive Regulation Of Phagocytosis, Engulfment Microglial Cell Proliferation Positive Regulation Of ERK1 And ERK2 Cascade Detection Of Lipoteichoic Acid Cellular Response To Lipoteichoic Acid Cellular Response To Peptidoglycan Regulation Of Macrophage Inflammatory Protein 1 Alpha Production Dendritic Cell Differentiation Amyloid-beta Clearance Import Into Cell Regulation Of Plasma Membrane Bounded Cell Projection Organization Complement-mediated Synapse Pruning Positive Regulation Of Amyloid-beta Clearance Positive Regulation Of Engulfment Of Apoptotic Cell Positive Regulation Of NIK/NF-kappaB Signaling Positive Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Inward Rectifier Potassium Channel Activity Regulation Of Intracellular Signal Transduction Positive Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of C-C Chemokine Receptor CCR7 Signaling Pathway Positive Regulation Of Microglial Cell Activation Negative Regulation Of Autophagic Cell Death Positive Regulation Of Microglial Cell Migration Cellular Response To Amyloid-beta Positive Regulation Of CAMKK-AMPK Signaling Cascade Positive Regulation Of CD40 Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Post-translational modification: synthesis of GPI-anchored proteins	Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell DAP12 interactions DAP12 signaling DAP12 signaling Other semaphorin interactions
Drugs
Diseases			Polycystic lipomembranous osteodysplasia with sclerosing leukoencephalopathy (PLOSL); Nasu-Hakola disease
GWAS		Schizophrenia ( 25056061 29483656)	Alzheimer's disease ( 23150908) Alzheimer's disease (late onset) ( 28714976) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Blood protein levels ( 30072576) C-reactive protein ( 22939635) Family history of Alzheimer's disease ( 30617256) Supraventricular ectopy ( 29618737)
Interacting Genes		1 interacting genes: TREM2	10 interacting genes: APOA1 APOA2 APOB APOE CLU GH1 NRN1L SCGB2A2 TYROBP UNC5B
Entrez ID		123904	54209
HPRD ID		18261	05473
Ensembl ID		ENSG00000188038	ENSG00000095970
Uniprot IDs		Q496H8	Q5TCX1 Q9NZC2
PDB IDs			5ELI 5UD7 5UD8 6B8O
Enriched GO Terms of Interacting Partners?
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