CCR4 and GRK3

Number of citations of the paper that reports this interaction (PubMedID 10754297)
32

Data Source:
HPRD (in vivo)

		CCR4	GRK3
Description		C-C motif chemokine receptor 4	G protein-coupled receptor kinase 3
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cell Plasma Membrane Integral Component Of Plasma Membrane External Side Of Plasma Membrane Neuronal Cell Body	Cytosol Plasma Membrane
	Molecular Function	Chemokine Receptor Activity Protein Binding C-C Chemokine Receptor Activity Chemokine Binding C-C Chemokine Binding	Protein Kinase Activity G Protein-coupled Receptor Kinase Activity Protein Binding ATP Binding Beta-adrenergic Receptor Kinase Activity
	Biological Process	Neuron Migration Tolerance Induction Chemotaxis Inflammatory Response Immune Response G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Cytosolic Calcium Ion Concentration Response To Radiation Response To Bacterium Calcium-mediated Signaling Response To Antibiotic Homeostasis Of Number Of Cells Positive Regulation Of Positive Chemotaxis Cell Chemotaxis Chemokine-mediated Signaling Pathway	Protein Phosphorylation Signal Transduction G Protein-coupled Receptor Signaling Pathway Receptor Internalization
Pathways		Chemokine receptors bind chemokines G alpha (i) signalling events	G alpha (s) signalling events Cargo recognition for clathrin-mediated endocytosis
Drugs			ATP
Diseases
GWAS		Celiac disease ( 22057235 20190752) Multiple sclerosis ( 24076602) Psychosis proneness (hypomanic personality scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (perceptual aberration scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised physical anhedonia scale and revised social anhedonia scale) ( 28525603) Psychosis proneness (revised social anhedonia scale) ( 28525603)
Interacting Genes		6 interacting genes: CCL17 CCL22 CCL3 CCL5 GRK2 GRK3	10 interacting genes: ADRB2 AGTR1 BDKRB2 CCR4 CCR5 CXCR4 GIT1 HSPB1 OPRM1 SMURF1
Entrez ID		1233	157
HPRD ID		05324	00183
Ensembl ID		ENSG00000183813	ENSG00000100077
Uniprot IDs		A0N0Q1 P51679	A0A024R1D8 P35626 Q8N433
PDB IDs
Enriched GO Terms of Interacting Partners?
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