CKS1B and CCNA1

Number of citations of the paper that reports this interaction (PubMedID 19786724)
8

Data Source:
BioGRID (pull down)

		CKS1B	CCNA1
Description		CDC28 protein kinase regulatory subunit 1B	cyclin A1
Image			No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleoplasm SCF Ubiquitin Ligase Complex	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Nucleoplasm Cytoplasm Cytosol Microtubule Cytoskeleton Cyclin A1-CDK2 Complex Cyclin A2-CDK2 Complex
	Molecular Function	Protein Binding Protein Kinase Binding Histone Binding Ubiquitin Binding Cyclin-dependent Protein Serine/threonine Kinase Activator Activity	Protein Kinase Activity Protein Binding Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding
	Biological Process	Regulation Of Transcription, DNA-templated Regulation Of Mitotic Cell Cycle Cell Proliferation Mitotic Cell Cycle Phase Transition Positive Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Cell Division	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Regulation Of Transcription Involved In G1/S Transition Of Mitotic Cell Cycle Protein Phosphorylation Male Meiosis I Spermatogenesis Protein Deubiquitination Mitotic Cell Cycle Phase Transition Cell Division
Pathways		SCF(Skp2)-mediated degradation of p27/p21 Cyclin D associated events in G1	G0 and Early G1 Phosphorylation of proteins involved in the G2/M transition by Cyclin A:Cdc2 complexes Cdc20:Phospho-APC/C mediated degradation of Cyclin A Regulation of APC/C activators between G1/S and early anaphase SCF(Skp2)-mediated degradation of p27/p21 Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence Ub-specific processing proteases Processing of DNA double-strand break ends TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Regulation of TP53 Activity through Phosphorylation Regulation of TP53 Degradation G2 Phase Orc1 removal from chromatin CDK-mediated phosphorylation and removal of Cdc6 G1/S-Specific Transcription Cyclin A/B1/B2 associated events during G2/M transition Cyclin A/B1/B2 associated events during G2/M transition p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry
Drugs		Fluoxetine Meta Vanadate
Diseases
GWAS		Bipolar disorder ( 31043756) Body fat distribution (leg fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Prostate cancer ( 23535732)	Cocaine dependence ( 31212010) Nickel levels ( 26025379)
Interacting Genes		32 interacting genes: AP2M1 ARID5A CBY2 CCNA1 CCNB2 CDC27 CDC37 CDK2 CDKN1B CDX4 CKS1BP7 CKS2 CUL1 DUSP1 ECPAS HSP90AA1 IKZF1 KRTAP10-9 KRTAP5-9 LDHB MEOX1 MIPOL1 PSMD9 REL ROPN1 SEPTIN3 SKP2 SSBP1 SUMO1P1 TCF4 TRIM27 XIAP	35 interacting genes: ARID2 BRCA1 BRCA2 CABLES1 CDC20 CDC25A CDK1 CDK2 CDKN1A CDKN1B CKS1B CKS2 CUX1 E2F1 GPS2 H1-1 H1-5 H2BC1 INCA1 KLHDC9 MCM4 MCM6 MYBL2 NPAT PGR PROCA1 RACK1 RB1 RBL1 RBL2 RBM4 RPA1 SP1 SRC XRCC6
Entrez ID		1163	8900
HPRD ID		00299	04946
Ensembl ID		ENSG00000173207	ENSG00000133101
Uniprot IDs		P61024 Q5T178	A0A140VJG0 P78396
PDB IDs		1BUH 1DKS 1DKT 2ASS 2AST 4YC6
Enriched GO Terms of Interacting Partners?
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