CISH and EPOR

Number of citations of the paper that reports this interaction (PubMedID 7796808)
123

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology)
HPRD (in vitro, in vivo, two hybrid)

		CISH	EPOR
Description		cytokine inducible SH2 containing protein	erythropoietin receptor
Image		No pdb structure
GO Annotations	Cellular Component	Cellular_component Cytosol Plasma Membrane Phosphatidylinositol 3-kinase Complex	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Nuclear Speck
	Molecular Function	Molecular_function Protein Binding 1-phosphatidylinositol-3-kinase Regulator Activity	Erythropoietin Receptor Activity Protein Binding Identical Protein Binding
	Biological Process	Regulation Of Cell Growth Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Protein Ubiquitination Intracellular Signal Transduction Interleukin-7-mediated Signaling Pathway Regulation Of Phosphatidylinositol 3-kinase Activity Post-translational Protein Modification Phosphatidylinositol Phosphorylation	Signal Transduction Brain Development Heart Development Positive Regulation Of Phosphatidylinositol 3-kinase Signaling Erythropoietin-mediated Signaling Pathway Positive Regulation Of Ras Protein Signal Transduction Decidualization
Pathways		Interleukin-7 signaling Neddylation Growth hormone receptor signaling	Signaling by Erythropoietin Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phosphoinositide-3-kinase (PI3K) Erythropoietin activates Phospholipase C gamma (PLCG) Erythropoietin activates STAT5 Erythropoietin activates RAS Erythropoietin activates RAS
Drugs			Darbepoetin alfa Erythropoietin Dibromotyrosine Peginesatide Methoxy polyethylene glycol-epoetin beta
Diseases			Congenital polycythemia; Familial erythrocytosis (ECYT)
GWAS		Cholangiocarcinoma in primary sclerosing cholangitis (time to event) ( 28779025)	Coronary artery disease ( 29212778) Serum erythropoietin levels ( 30271932)
Interacting Genes		18 interacting genes: CSF2RB CSF3R EPOR ERBB2 ETV5 GHR GPX1 HSPA6 IL2RB IL3RA KIT MAP3K7CL MYD88 PRKCA PRKCB PRKCQ PRLR SMAD2	39 interacting genes: ATXN2L CBL CISH CRKL CSF2RB EGLN3 ELOB ELOC EPO GAB1 GAB2 GNAI1 GRAP GRB2 INPP5D IRS2 JAK2 KIT KITLG KLK3 LYN MAPK1 MAPK3 MST1R PIK3R1 PLCG1 PLCG2 PTPN11 PTPN6 RACK1 SH2B2 SHC1 SOCS2 SOCS3 STAT5A STAT5B SYK VAV1 VHL
Entrez ID		1154	2057
HPRD ID		03897	00587
Ensembl ID		ENSG00000114737	ENSG00000187266
Uniprot IDs		Q9NSE2	P19235
PDB IDs			1CN4 1EBA 1EBP 1EER 1ERN 2JIX 2MV6 4Y5V 4Y5X 4Y5Y 6E2Q 6MOE 6MOF 6MOH 6MOI 6MOJ 6MOK 6MOL
Enriched GO Terms of Interacting Partners?
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