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CHUK and CUL1
Number of citations of the paper that reports this interaction (PubMedID
17914462
)
85
Data Source:
HPRD
(in vivo)
CHUK
CUL1
Description
component of inhibitor of nuclear factor kappa B kinase complex
cullin 1
Image
GO Annotations
Cellular Component
Nucleoplasm
Cytoplasm
Cytosol
IkappaB Kinase Complex
Cytoplasmic Side Of Plasma Membrane
CD40 Receptor Complex
Intracellular Membrane-bounded Organelle
Cell
Nucleoplasm
Cytosol
SCF Ubiquitin Ligase Complex
Cullin-RING Ubiquitin Ligase Complex
Parkin-FBXW7-Cul1 Ubiquitin Ligase Complex
Molecular Function
Protein Kinase Activity
Protein Serine/threonine Kinase Activity
Protein Binding
ATP Binding
IkappaB Kinase Activity
Protein Homodimerization Activity
Protein-containing Complex Binding
Protein Heterodimerization Activity
Scaffold Protein Binding
Transferrin Receptor Binding
Protein Binding
Ubiquitin Protein Ligase Binding
Biological Process
Stimulatory C-type Lectin Receptor Signaling Pathway
Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent
MyD88-independent Toll-like Receptor Signaling Pathway
Skeletal Muscle Contraction
Protein Phosphorylation
Inflammatory Response
Immune Response
I-kappaB Kinase/NF-kappaB Signaling
I-kappaB Phosphorylation
Rho Protein Signal Transduction
Response To Virus
Response To Toxic Substance
Anatomical Structure Morphogenesis
Response To Acetate
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Peptidyl-serine Phosphorylation
Negative Regulation Of NF-kappaB Transcription Factor Activity
Response To Lipopolysaccharide
Response To Hydroperoxide
Tumor Necrosis Factor-mediated Signaling Pathway
Cellular Response To Reactive Oxygen Species
TRIF-dependent Toll-like Receptor Signaling Pathway
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Response To Drug
Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Response To Amino Acid
Innate Immune Response
Positive Regulation Of Transcription, DNA-templated
Positive Regulation Of Transcription By RNA Polymerase II
T Cell Receptor Signaling Pathway
Positive Regulation Of NF-kappaB Transcription Factor Activity
Striated Muscle Cell Differentiation
Stress-activated MAPK Cascade
Response To Cholecystokinin
Interleukin-1-mediated Signaling Pathway
Cellular Response To Cadmium Ion
Cellular Response To Tumor Necrosis Factor
Cellular Response To Virus
Positive Regulation Of Interferon-alpha Secretion
G1/S Transition Of Mitotic Cell Cycle
G2/M Transition Of Mitotic Cell Cycle
Protein Polyubiquitination
Stimulatory C-type Lectin Receptor Signaling Pathway
Ubiquitin-dependent Protein Catabolic Process
Protein Monoubiquitination
Cellular Iron Ion Homeostasis
Cell Proliferation
Animal Organ Morphogenesis
SCF Complex Assembly
Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle
Viral Process
Wnt Signaling Pathway
Protein Ubiquitination
SCF-dependent Proteasomal Ubiquitin-dependent Protein Catabolic Process
NIK/NF-kappaB Signaling
Fc-epsilon Receptor Signaling Pathway
Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Post-translational Protein Modification
T Cell Receptor Signaling Pathway
Stress-activated MAPK Cascade
Interleukin-1-mediated Signaling Pathway
Intrinsic Apoptotic Signaling Pathway
Regulation Of Mitotic Cell Cycle Phase Transition
Pathways
Activation of NF-kappaB in B cells
Activation of NF-kappaB in B cells
ER-Phagosome pathway
NOD1/2 Signaling Pathway
TICAM1, RIP1-mediated IKK complex recruitment
RIP-mediated NFkB activation via ZBP1
AKT phosphorylates targets in the cytosol
Downstream TCR signaling
FCERI mediated NF-kB activation
TAK1 activates NFkB by phosphorylation and activation of IKKs complex
Regulation of TNFR1 signaling
TNFR1-induced NFkappaB signaling pathway
IKBKB deficiency causes SCID
IKBKG deficiency causes anhidrotic ectodermal dysplasia with immunodeficiency (EDA-ID) (via TLR)
IkBA variant leads to EDA-ID
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Constitutive Signaling by AKT1 E17K in Cancer
NIK - noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Interleukin-1 signaling
TRAF6 mediated NF-kB activation
NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10
IRAK1 recruits IKK complex
IKK complex recruitment mediated by RIP1
IRAK1 recruits IKK complex upon TLR7/8 or 9 stimulation
Activation of NF-kappaB in B cells
Prolactin receptor signaling
SCF-beta-TrCP mediated degradation of Emi1
SCF(Skp2)-mediated degradation of p27/p21
Degradation of beta-catenin by the destruction complex
Downstream TCR signaling
NOTCH1 Intracellular Domain Regulates Transcription
Regulation of PLK1 Activity at G2/M Transition
Constitutive Signaling by NOTCH1 PEST Domain Mutants
Loss of Function of FBXW7 in Cancer and NOTCH1 Signaling
FCERI mediated NF-kB activation
Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants
Circadian Clock
Dectin-1 mediated noncanonical NF-kB signaling
CLEC7A (Dectin-1) signaling
Degradation of GLI1 by the proteasome
Degradation of GLI2 by the proteasome
GLI3 is processed to GLI3R by the proteasome
NIK - noncanonical NF-kB signaling
MAP3K8 (TPL2)-dependent MAPK1/3 activation
Orc1 removal from chromatin
Cyclin D associated events in G1
FBXL7 down-regulates AURKA during mitotic entry and in early mitosis
Regulation of RUNX2 expression and activity
Regulation of RUNX2 expression and activity
Neddylation
Interleukin-1 signaling
Iron uptake and transport
Negative regulation of NOTCH4 signaling
Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Aminosalicylic Acid
Mesalazine
Sulfasalazine
Acetylcysteine
Diseases
Cocoon syndrome
GWAS
Liver enzyme levels (
18940312
)
Psoriasis (
28537254
)
Type 2 diabetes (
30054458
)
Crohn's disease (
28067908
)
Inflammatory bowel disease (
28067908
)
Metabolite levels (
23823483
)
Uterine fibroid size (maximum volume) (
30196971
)
Interacting Genes
81 interacting genes:
AKT1
AKT2
AMBRA1
ATR
BCL10
BCL3
BTRC
CASP8
CDC37
CHEK1
COPS5
CREBBP
CSF2RA
CSNK2A1
CTNNB1
CUEDC2
CUL1
DCUN1D5
E2F4
EIF2AK2
ELP1
ERBIN
ESR1
FKBP5
FOXO3
H3-4
H3C14
HSP90AA1
HSP90AB1
HTT
IFIT5
IKBKB
IKBKE
IKBKG
IRS1
MAP3K1
MAP3K11
MAP3K14
MAP3K4
MAP3K7
MAP3K8
NCOA3
NCOR1
NCOR2
NFKB1
NFKB2
NFKBIA
NFKBIB
NLRP4
NOTCH3
NR2C2
PAX8
PEBP1
PIAS1
PRKCB
PRKCI
PRKCQ
PRKDC
PTPN11
RELA
RICTOR
RIPK2
RPL27
SRC
SRPK1
SRPK2
STAP2
TANK
TGFBR1
TNFAIP3
TNFRSF1A
TP53
TRAF2
TRAF3IP2
TRAF4
TRIM27
TRPC4AP
UBC
UBE2E3
UBE2I
UBE2N
57 interacting genes:
BTRC
CAND1
CDC34
CDCA3
CDK9
CDKN1B
CENPE
CENPW
CHEK1
CHUK
CKS1B
COMMD1
COPS2
COPS5
COPS6
COPS8
DLEU2
E2F1
FBH1
FBXO25
FBXW11
FBXW2
FBXW4
FBXW7
GHR
GPS1
HIPK2
KHNYN
NEDD8
NFKBIA
NFKBIB
NFKBIE
NLK
NLRP3
NR1D2
PPP1CA
PRKN
PRPF40A
PSMB4
PSMD4
PTTG1
RAC2
RANBP2
RBX1
RICTOR
RNF7
SENP8
SKP1
SKP2
SMAD3
THRA
TRIM21
UBC
UBE2E3
UBE2F
UBE2M
ZC3HC1
Entrez ID
1147
8454
HPRD ID
02811
04389
Ensembl ID
ENSG00000213341
ENSG00000055130
Uniprot IDs
O15111
A0A090N7U0
B3KTW0
Q13616
PDB IDs
3BRT
5EBZ
5TQW
5TQX
5TQY
1LDJ
1LDK
1U6G
3RTR
3TDU
3TDZ
4F52
4P5O
5V89
Enriched GO Terms of Interacting Partners
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