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NLRP3 and PYCARD
Number of citations of the paper that reports this interaction (PubMedID
11786556
)
64
Data Source:
BioGRID
(affinity chromatography technology)
HPRD
(in vitro)
NLRP3
PYCARD
Description
NLR family pyrin domain containing 3
PYD and CARD domain containing
Image
GO Annotations
Cellular Component
Golgi Membrane
Extracellular Region
Nucleus
Cytoplasm
Endoplasmic Reticulum
Cytosol
NLRP3 Inflammasome Complex
Golgi Membrane
Extracellular Region
Nucleus
Nucleoplasm
Nucleolus
Cytoplasm
Mitochondrion
Endoplasmic Reticulum
Cytosol
IkappaB Kinase Complex
Protein-containing Complex
Secretory Granule Lumen
Azurophil Granule Lumen
Neuronal Cell Body
NLRP1 Inflammasome Complex
NLRP3 Inflammasome Complex
AIM2 Inflammasome Complex
Molecular Function
Protein Binding
ATP Binding
Transcription Factor Binding
Identical Protein Binding
Peptidoglycan Binding
Sequence-specific DNA Binding
Protease Binding
Interleukin-6 Receptor Binding
Protein Binding
Tropomyosin Binding
Cysteine-type Endopeptidase Activator Activity Involved In Apoptotic Process
Myosin I Binding
Enzyme Binding
Pyrin Domain Binding
Identical Protein Binding
Protein Homodimerization Activity
Ion Channel Binding
Protein Dimerization Activity
BMP Receptor Binding
Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Biological Process
Cytokine Secretion Involved In Immune Response
Negative Regulation Of Acute Inflammatory Response
Positive Regulation Of Type 2 Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Defense Response
Inflammatory Response
Signal Transduction
Detection Of Biotic Stimulus
Protein Deubiquitination
Negative Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1 Beta Production
Interleukin-18 Production
Positive Regulation Of Interleukin-13 Production
Positive Regulation Of Interleukin-4 Production
Positive Regulation Of Interleukin-5 Production
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
NLRP3 Inflammasome Complex Assembly
Innate Immune Response
Positive Regulation Of T-helper 2 Cell Differentiation
Positive Regulation Of Transcription By RNA Polymerase II
Interleukin-1 Secretion
Negative Regulation Of Interleukin-1 Beta Secretion
Positive Regulation Of Interleukin-1 Beta Secretion
Negative Regulation Of Inflammatory Response
Defense Response To Gram-positive Bacterium
Positive Regulation Of NF-kappaB Transcription Factor Activity
Defense Response To Virus
Cellular Response To Lipopolysaccharide
Cellular Response To Peptidoglycan
Negative Regulation Of NIK/NF-kappaB Signaling
Positive Regulation Of T-helper 17 Cell Differentiation
Positive Regulation Of T-helper 2 Cell Cytokine Production
Myeloid Dendritic Cell Activation
Activation Of Innate Immune Response
Positive Regulation Of Defense Response To Virus By Host
Myeloid Dendritic Cell Activation Involved In Immune Response
Positive Regulation Of Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II
Positive Regulation Of Adaptive Immune Response
Apoptotic Process
Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Inflammatory Response
Signal Transduction
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Regulation Of Autophagy
Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Actin Filament Polymerization
Regulation Of Protein Stability
Negative Regulation Of NF-kappaB Transcription Factor Activity
Interleukin-1 Beta Production
Negative Regulation Of Interferon-beta Production
Positive Regulation Of Interferon-gamma Production
Positive Regulation Of Interleukin-1 Beta Production
Positive Regulation Of Interleukin-6 Production
Positive Regulation Of Tumor Necrosis Factor Production
Tumor Necrosis Factor-mediated Signaling Pathway
Positive Regulation Of Activated T Cell Proliferation
Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage By P53 Class Mediator
Positive Regulation Of Apoptotic Process
Regulation Of GTPase Activity
Negative Regulation Of I-kappaB Kinase/NF-kappaB Signaling
Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process
Neutrophil Degranulation
Macropinocytosis
Innate Immune Response
Positive Regulation Of JNK Cascade
Positive Regulation Of Interleukin-1 Beta Secretion
Positive Regulation Of Phagocytosis
Defense Response To Gram-negative Bacterium
Positive Regulation Of T Cell Activation
Positive Regulation Of DNA-binding Transcription Factor Activity
Positive Regulation Of NF-kappaB Transcription Factor Activity
Protein Homooligomerization
Defense Response To Virus
Positive Regulation Of ERK1 And ERK2 Cascade
Cellular Response To Lipopolysaccharide
Cellular Response To Interleukin-1
Cellular Response To Tumor Necrosis Factor
Negative Regulation Of Protein Serine/threonine Kinase Activity
Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator
Positive Regulation Of Chemokine Secretion
Positive Regulation Of Release Of Cytochrome C From Mitochondria
Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand
Activation Of Cysteine-type Endopeptidase Activity
Negative Regulation Of Cytokine Production Involved In Inflammatory Response
Positive Regulation Of T Cell Migration
Positive Regulation Of Interleukin-8 Secretion
Positive Regulation Of Interleukin-6 Secretion
Positive Regulation Of Cysteine-type Endopeptidase Activity
Positive Regulation Of Interleukin-10 Secretion
Positive Regulation Of Extrinsic Apoptotic Signaling Pathway
Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways
Metalloprotease DUBs
The NLRP3 inflammasome
The NLRP3 inflammasome
Purinergic signaling in leishmaniasis infection
Purinergic signaling in leishmaniasis infection
CLEC7A/inflammasome pathway
Neutrophil degranulation
The NLRP3 inflammasome
The AIM2 inflammasome
Purinergic signaling in leishmaniasis infection
Drugs
Diseases
Cryopyrin associated periodic syndrome (CAPS), including the following three diseases: Muckle-Wells syndrome (MWS); Familial cold autoinflammatory syndrome (FCAS); Chronic infantile neurologic, cutaneous, articular (CINCA) syndrome
GWAS
C-reactive protein levels (
30388399
21300955
)
Fibrinogen (
20031576
23969696
)
Fibrinogen levels (
28107422
26561523
)
Granulocyte count (
27863252
)
Myeloid white cell count (
27863252
)
Neutrophil count (
27863252
)
Neutrophil percentage of white cells (
27863252
)
Platelet count (
27863252
)
Sum basophil neutrophil counts (
27863252
)
Sum neutrophil eosinophil counts (
27863252
)
Waist circumference adjusted for body mass index (
25673412
)
White blood cell count (
27863252
)
Word reading (
23738518
)
Post bronchodilator FEV1 (
26634245
)
Interacting Genes
8 interacting genes:
ATP1B3
CARD8
CUL1
FAF1
FBXL2
PGM1
PYCARD
TRIM31
12 interacting genes:
CASP1
EXOC5
MEFV
NLRC4
NLRP1
NLRP12
NLRP3
POP1
PRKAR1A
PYDC2
SRF
USP50
Entrez ID
114548
29108
HPRD ID
05915
06020
Ensembl ID
ENSG00000162711
ENSG00000103490
Uniprot IDs
Q96P20
Q9ULZ3
PDB IDs
2NAQ
3QF2
6NPY
1UCP
2KN6
3J63
5H8O
6N1H
Enriched GO Terms of Interacting Partners
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