CHRM1 and RGS7

Number of citations of the paper that reports this interaction (PubMedID 19182865)
28

Data Source:
BioGRID (pull down)

		CHRM1	RGS7
Description		cholinergic receptor muscarinic 1	regulator of G protein signaling 7
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Cell Junction Dendrite Axon Terminus Synapse Schaffer Collateral - CA1 Synapse Glutamatergic Synapse Cholinergic Synapse Integral Component Of Presynaptic Membrane Integral Component Of Postsynaptic Density Membrane	Cytosol Plasma Membrane
	Molecular Function	Phosphatidylinositol Phospholipase C Activity G Protein-coupled Receptor Activity G Protein-coupled Serotonin Receptor Activity Protein Binding G Protein-coupled Acetylcholine Receptor Activity Neurotransmitter Receptor Activity Neurotransmitter Receptor Activity Involved In Regulation Of Postsynaptic Membrane Potential	GTPase Activity GTPase Activator Activity G-protein Beta-subunit Binding
	Biological Process	Signal Transduction G Protein-coupled Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway, Coupled To Cyclic Nucleotide Second Messenger Adenylate Cyclase-inhibiting G Protein-coupled Acetylcholine Receptor Signaling Pathway Protein Kinase C-activating G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Acetylcholine Receptor Signaling Pathway Chemical Synaptic Transmission Neuromuscular Synaptic Transmission Nervous System Development Regulation Of Locomotion Positive Regulation Of Ion Transport Saliva Secretion Cognition Regulation Of Postsynaptic Membrane Potential Regulation Of Glial Cell Proliferation Positive Regulation Of Intracellular Protein Transport G Protein-coupled Serotonin Receptor Signaling Pathway	Protein Folding G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Signal Transduction Intracellular Signal Transduction Positive Regulation Of GTPase Activity
Pathways		Muscarinic acetylcholine receptors G alpha (q) signalling events	G alpha (i) signalling events G alpha (i) signalling events Cooperation of PDCL (PhLP1) and TRiC/CCT in G-protein beta folding
Drugs		Cevimeline Succinylcholine Trospium Citalopram Oxyphenonium Benzatropine Ziprasidone Disopyramide Amitriptyline Ipratropium bromide Olanzapine Metixene Terfenadine Buclizine Clozapine Doxylamine Trihexyphenidyl Oxyphencyclimine Procyclidine Ethopropazine Loxapine Carbachol Promazine Hyoscyamine Cyproheptadine Pethidine Imipramine Methylscopolamine bromide Chlorpromazine Gallamine Triethiodide Darifenacin Tridihexethyl Triflupromazine Anisotropine Methylbromide Nortriptyline Amoxapine Amoxapine Cinnarizine Atropine Nicardipine Pirenzepine Paroxetine Homatropine Methylbromide Trimipramine Scopolamine Benzquinamide Clidinium Propiomazine Propantheline Cryptenamine Dicyclomine Minaprine Tropicamide Biperiden Brompheniramine Flupentixol Cocaine Maprotiline Methantheline Cycrimine Cyclopentolate Glycopyrronium Bethanechol Tolterodine Oxybutynin Promethazine Pilocarpine Doxepin Flavoxate Desipramine Escitalopram Ketamine Quetiapine Diphenidol Metoclopramide Aripiprazole Chlorprothixene Methotrimeprazine Tiotropium Solifenacin Molindone Staurosporine Acetylcholine Arecoline Mepenzolate NGX267 ALKS 27 ACP-104 Fesoterodine Hexocyclium Aclidinium Umeclidinium Dosulepin Etoperidone Imidafenacin
Diseases
GWAS		Urate levels ( 31578528)	Chronotype ( 30696823) Diastolic blood pressure ( 29208002) Ischemic stroke (cardioembolic) ( 29531354) Longevity (90 years and older) ( 25199915) Major depressive disorder ( 27479909) Obesity-related traits ( 23251661) Post bronchodilator FEV1 ( 26634245) Western dietary pattern ( 28644415)
Interacting Genes		5 interacting genes: CDC14A GNAI2 GPRASP1 GPRASP2 RGS7	16 interacting genes: CHRM1 CHRM2 CHRM3 CHRM5 GNAI1 GNAI3 GNAO1 GNAQ GNAZ GNB5 MSX1 PKD1 PRKCA SNAPIN YWHAB YWHAQ
Entrez ID		1128	6000
HPRD ID		00338	03948
Ensembl ID		ENSG00000168539	ENSG00000182901
Uniprot IDs		P11229 Q53XZ3	B7Z223 B7Z257 P49802
PDB IDs		5CXV 6OIJ	2A72 2D9J
Enriched GO Terms of Interacting Partners?
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