PACSIN2 and WASL

Number of citations of the paper that reports this interaction (PubMedID 12426380)
69

Data Source:
HPRD (two hybrid)

		PACSIN2	WASL
Description		protein kinase C and casein kinase substrate in neurons 2	WASP like actin nucleation promoting factor
Image
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Cytosol Cytoskeleton Plasma Membrane Caveola Cell-cell Junction Focal Adhesion Nuclear Speck Extrinsic Component Of Membrane Cytoplasmic Vesicle Membrane Ruffle Membrane Intracellular Membrane-bounded Organelle Recycling Endosome Membrane Extracellular Exosome Glutamatergic Synapse	Cell Nucleus Cytosol Actin Filament Plasma Membrane Actin Cytoskeleton Lamellipodium Actin Cap Actin Cortical Patch Endocytic Vesicle Membrane Cytoplasmic Vesicle Extracellular Exosome
	Molecular Function	Transporter Activity Protein Binding Phospholipid Binding Cytoskeletal Protein Binding Identical Protein Binding Cadherin Binding Phosphatidic Acid Binding	Protein Binding GTPase Regulator Activity Actin Filament Binding
	Biological Process	Cytoskeleton Organization Actin Cytoskeleton Organization Regulation Of Endocytosis Protein Localization To Endosome Negative Regulation Of Endocytosis Cell Projection Morphogenesis Modulation Of Chemical Synaptic Transmission Membrane Organization Caveola Assembly Caveolin-mediated Endocytosis Plasma Membrane Tubulation	Actin Cortical Patch Assembly Endocytosis Vesicle Budding From Membrane Actin Polymerization Or Depolymerization Regulation Of Cell Shape Response To Bacterium Vesicle Organization Actin Filament Polymerization Actin Filament-based Movement Vesicle Transport Along Actin Filament Regulation Of Protein Localization Cellular Protein-containing Complex Localization Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Regulation Of Nitric-oxide Synthase Activity Positive Regulation Of Actin Nucleation Cell Division Positive Regulation Of Filopodium Assembly Spindle Localization Actin Cortical Patch Localization Dendritic Spine Morphogenesis Membrane Organization Protein-containing Complex Assembly Negative Regulation Of Membrane Tubulation Positive Regulation Of Clathrin-dependent Endocytosis Negative Regulation Of Lymphocyte Migration Positive Regulation Of Arp2/3 Complex-mediated Actin Nucleation
Pathways		Clathrin-mediated endocytosis	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation NOSTRIN mediated eNOS trafficking Nephrin family interactions EPHB-mediated forward signaling EPHB-mediated forward signaling DCC mediated attractive signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs
Diseases
GWAS		Mean platelet volume ( 27863252) Platelet count ( 27863252) Platelet distribution width ( 27863252) Prostate cancer (SNP x SNP interaction) ( 22219177)	Platelet count ( 22139419 27863252) Plateletcrit ( 27863252)
Interacting Genes		12 interacting genes: DNM1 FASLG MEOX2 PACSIN1 PACSIN3 POT1 SHBG SYNJ1 TERF1 TERF2IP TRPV4 WASL	51 interacting genes: AASS ABL1 ACTG1 ACTR2 ACTR3 APBB1 APP ARPC3 BIN1 CDC42 CORO7 CTTN DNMBP EGFR EVL FCHSD2 FNBP1 FNBP1L GRB2 HP HSP90AA1 HSP90AB1 IPO5 ITSN1 ITSN2 LCK NCK1 NCK2 NCKIPSD PACSIN1 PACSIN2 PACSIN3 PFN1 PRMT2 PRPF40A PSTPIP1 PTK6 RHOJ RHOQ RNF8 RPL7AP66 SDCBP SH3GL3 SNX9 SRC TRIP10 VASP VIPR1 WIPF1 WIPF2 ZNF395
Entrez ID		11252	8976
HPRD ID		05390	05448
Ensembl ID		ENSG00000100266	ENSG00000106299
Uniprot IDs		Q6FIA3 Q9UNF0	O00401
PDB IDs		3ABH 3ACO 3HAJ 3Q0K	2FF3 2LNH 2VCP 4CC2 4CC7
Enriched GO Terms of Interacting Partners?
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