CHM and RAB3D

Number of citations of the paper that reports this interaction (PubMedID 10022613)
2

Data Source:
HPRD (in vivo, in vitro)

		CHM	RAB3D
Description		CHM Rab escort protein	RAB3D, member RAS oncogene family
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Cytosol Rab-protein Geranylgeranyltransferase Complex	Endosome Cytoplasmic Microtubule Plasma Membrane Synaptic Vesicle Endomembrane System Cytoplasmic Vesicle Vesicle Azurophil Granule Membrane Zymogen Granule Extracellular Exosome Secretory Vesicle
	Molecular Function	Rab Geranylgeranyltransferase Activity GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Rab GTPase Binding	GTPase Activity GTP Binding GTP-dependent Protein Binding Myosin V Binding
	Biological Process	Protein Targeting To Membrane Small GTPase Mediated Signal Transduction Visual Perception Vesicle-mediated Transport Protein Geranylgeranylation Regulation Of Apoptotic Process Positive Regulation Of GTPase Activity Post-translational Protein Modification	Intracellular Protein Transport Vesicle Docking Involved In Exocytosis Protein Secretion Regulation Of Exocytosis Peptidyl-cysteine Methylation Rab Protein Signal Transduction Neutrophil Degranulation Bone Resorption Protein Localization To Plasma Membrane Positive Regulation Of Regulated Secretory Pathway
Pathways		TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs	Neutrophil degranulation RAB geranylgeranylation
Drugs
Diseases		Choroideremia (CHM); Tapetochoroidal dystrophy
GWAS		Metabolite levels ( 23823483) Pit-and-Fissure caries ( 24556642) Smooth-surface caries ( 24556642)	Early cardiac repolarization ( 31600170) HDL cholesterol ( 23505323)
Interacting Genes		11 interacting genes: RAB14 RAB18 RAB1B RAB32 RAB3A RAB3B RAB3D RAB4A RAB5B RAB6A RAB7A	12 interacting genes: AKT1 AKT2 AP1M2 APP CEP55 CHM CYP2C9 MAST1 RAB3IP RIMS2 RNF32 RPH3AL
Entrez ID		1121	9545
HPRD ID		02312	05070
Ensembl ID		ENSG00000188419	ENSG00000105514
Uniprot IDs		A8K545 B4DRL9 P24386	A0A024R7G2 O95716
PDB IDs			2GF9
Enriched GO Terms of Interacting Partners?
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