MAP4K1 and CARD11

Number of citations of the paper that reports this interaction (PubMedID 19706536)
27

Data Source:
BioGRID (affinity chromatography technology, enzymatic study)

		MAP4K1	CARD11
Description		mitogen-activated protein kinase kinase kinase kinase 1	caspase recruitment domain family member 11
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GO Annotations	Cellular Component	Cytoplasm Membrane	Immunological Synapse Cytoplasm Cytosol Plasma Membrane CBM Complex Membrane Raft Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding MAP Kinase Kinase Kinase Kinase Activity	Guanylate Kinase Activity Protein Binding CARD Domain Binding
	Biological Process	MAPK Cascade Activation Of MAPKKK Activity Protein Phosphorylation Activation Of JUN Kinase Activity Regulation Of Mitotic Cell Cycle Cell Proliferation Peptidyl-serine Phosphorylation Signal Transduction By Protein Phosphorylation Stress-activated Protein Kinase Signaling Cascade Activation Of Protein Kinase Activity Protein Autophosphorylation Cellular Response To Phorbol 13-acetate 12-myristate	Positive Regulation Of Cytokine Production Stimulatory C-type Lectin Receptor Signaling Pathway Immunoglobulin Production I-kappaB Kinase/NF-kappaB Signaling B Cell Differentiation Positive Regulation Of B Cell Proliferation T Cell Costimulation Fc-epsilon Receptor Signaling Pathway TORC1 Signaling B Cell Proliferation Positive Regulation Of T Cell Proliferation Regulation Of Apoptotic Process Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Thymic T Cell Selection Positive Regulation Of Interleukin-2 Biosynthetic Process Regulation Of B Cell Differentiation Regulation Of T Cell Differentiation GMP Metabolic Process GDP Metabolic Process Homeostasis Of Number Of Cells T Cell Receptor Signaling Pathway Positive Regulation Of NF-kappaB Transcription Factor Activity Interleukin-2 Secretion
Pathways			Activation of NF-kappaB in B cells Activation of NF-kappaB in B cells Downstream TCR signaling FCERI mediated NF-kB activation FCERI mediated NF-kB activation CLEC7A (Dectin-1) signaling
Drugs
Diseases
GWAS		Diisocyanate-induced asthma ( 25918132)	Atopic dermatitis ( 23042114) Cadmium levels ( 26025379) Daytime sleep phenotypes ( 27126917) Dupuytren's disease ( 28886342) Intracranial aneurysm ( 29531279) Multiple sclerosis ( 31604244 24076602) Response to fenofibrate (total cholesterol levels) ( 27002377) Ulcerative colitis ( 23128233) White matter integrity ( 23218918)
Interacting Genes		22 interacting genes: ABL1 BLNK CARD11 CASP3 CRK CRKL DAPP1 DBNL EGFR GRAP2 GRB2 H2AC4 HCLS1 LAT LCP2 LYN MAP3K11 MAP3K7 NCK1 SHC1 SYK TMEM101	15 interacting genes: BCL10 IKBKG MAP3K7 MAP4K1 PDPK1 PPP2CA PPP2R1A PRKCB PRKCQ RNF181 SH2D3C SRPK2 TAB1 WDR1 ZAP70
Entrez ID		11184	84433
HPRD ID		03583	06234
Ensembl ID		ENSG00000104814	ENSG00000198286
Uniprot IDs		Q92918	A0A024R854 Q8TES3 Q9BXL7
PDB IDs		6CQD 6CQE 6CQF 6NFY 6NFZ 6NG0	4JUP 4LWD
Enriched GO Terms of Interacting Partners?
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