Description |
checkpoint kinase 1 |
MDM4 regulator of p53 |
Image |
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GO Annotations |
Cellular Component |
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Molecular Function |
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Biological Process |
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Pathways |
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Drugs |
- XL844
- 4-[(3S)-1-AZABICYCLO[2.2.2]OCT-3-YLAMINO]-3-(1H-BENZIMIDAZOL-2-YL)-6-CHLOROQUINOLIN-2(1H)-ONE
- N-{5-[4-(4-METHYLPIPERAZIN-1-YL)PHENYL]-1H-PYRROLO[2,3-B]PYRIDIN-3-YL}NICOTINAMIDE
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)QUINOLIN-2(1H)-ONE
- 2,2'-{[9-(HYDROXYIMINO)-9H-FLUORENE-2,7-DIYL]BIS(OXY)}DIACETIC ACID
- (2S)-1-AMINO-3-[(5-NITROQUINOLIN-8-YL)AMINO]PROPAN-2-OL
- 2-(cyclohexylamino)benzoic acid
- 3-(5-{[4-(AMINOMETHYL)PIPERIDIN-1-YL]METHYL}-1H-INDOL-2-YL)-1H-INDAZOLE-6-CARBONITRILE
- (3Z)-6-(4-HYDROXY-3-METHOXYPHENYL)-3-(1H-PYRROL-2-YLMETHYLENE)-1,3-DIHYDRO-2H-INDOL-2-ONE
- 5-ETHYL-3-METHYL-1,5-DIHYDRO-4H-PYRAZOLO[4,3-C]QUINOLIN-4-ONE
- (5-{3-[5-(PIPERIDIN-1-YLMETHYL)-1H-INDOL-2-YL]-1H-INDAZOL-6-YL}-2H-1,2,3-TRIAZOL-4-YL)METHANOL
- 1-(5-CHLORO-2-METHOXYPHENYL)-3-{6-[2-(DIMETHYLAMINO)-1-METHYLETHOXY]PYRAZIN-2-YL}UREA
- (3-ENDO)-8-METHYL-8-AZABICYCLO[3.2.1]OCT-3-YL 1H-PYRROLO[2,3-B]PYRIDINE-3-CARBOXYLATE
- 18-CHLORO-11,12,13,14-TETRAHYDRO-1H,10H-8,4-(AZENO)-9,15,1,3,6-BENZODIOXATRIAZACYCLOHEPTADECIN-2-ONE
- 1-(5-CHLORO-2,4-DIMETHOXYPHENYL)-3-(5-CYANOPYRAZIN-2-YL)UREA
- 4-(6-{[(4-METHYLCYCLOHEXYL)AMINO]METHYL}-1,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)BENZOIC ACID
- 4-[3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOL-6-YL]-2-METHOXYPHENOL
- (2R)-1-[(5,6-DIPHENYL-7H-PYRROLO[2,3-D]PYRIMIDIN-4-YL)AMINO]PROPAN-2-OL
- (2R)-3-{[(4Z)-5,6-DIPHENYL-6,7-DIHYDRO-4H-PYRROLO[2,3-D]PYRIMIDIN-4-YLIDENE]AMINO}PROPANE-1,2-DIOL
- N-(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)GLYCINE
- (5,6-DIPHENYL-FURO[2,3-D]PYRIMIDIN-4-YLAMINO)-ACETIC
- 3-AMINO-3-BENZYL-[4.3.0]BICYCLO-1,6-DIAZANONAN-2-ONE
- 3-(1H-BENZIMIDAZOL-2-YL)-1H-INDAZOLE
- 2-[5,6-BIS-(4-METHOXY-PHENYL)-FURO[2,3-D]PYRIMIDIN-4-YLAMINO]-ETHANOL
- 2-[(5,6-DIPHENYLFURO[2,3-D]PYRIMIDIN-4-YL)AMINO]ETHANOL
- REL-(9R,12S)-9,10,11,12-TETRAHYDRO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-1,3(2H)-DIONE
- 1-[(2S)-4-(5-phenyl-1H-pyrazolo[3,4-b]pyridin-4-yl)morpholin-2-yl]methanamine
- N-(4-OXO-5,6,7,8-TETRAHYDRO-4H-[1,3]THIAZOLO[5,4-C]AZEPIN-2-YL)ACETAMIDE
- 5,6,7,8-TETRAHYDRO[1]BENZOTHIENO[2,3-D]PYRIMIDIN-4(3H)-ONE
- [4-amino-2-(tert-butylamino)-1,3-thiazol-5-yl](phenyl)methanone
- 2-(methylsulfanyl)-5-(thiophen-2-ylmethyl)-1H-imidazol-4-ol
- 6-MORPHOLIN-4-YL-9H-PURINE
- 1-[(2S)-4-(5-BROMO-1H-PYRAZOLO[3,4-B]PYRIDIN-4-YL)MORPHOLIN-2-YL]METHANAMINE
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Diseases |
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GWAS |
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- Breast cancer ( 23535733 27117709)
- Breast cancer (estrogen-receptor negative) ( 27117709 29058716)
- Breast cancer (estrogen-receptor negative, progesterone-receptor negative, and human epidermal growth factor-receptor negative) ( 24325915)
- Breast Cancer in BRCA1 mutation carriers ( 23544013)
- Cognitive performance ( 19734545)
- Diastolic blood pressure ( 27618452 30578418)
- Diastolic blood pressure (cigarette smoking interaction) ( 29455858)
- Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962)
- Glioma ( 28346443)
- Non-glioblastoma glioma ( 28346443)
- Prostate cancer ( 23535732)
- Regular attendance at a religious group ( 29970889)
- Systolic blood pressure ( 27618452)
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Interacting Genes |
52 interacting genes:
AATF
AKT1
APP
ATM
ATR
ATXN3
BCL2L1
BLM
BRCA1
BRCA2
CDC25A
CDC25B
CDC25C
CHUK
CLSPN
CNTN2
CSNK2B
CUL1
CUL4A
DTL
FANCE
HSP90AA1
ILKAP
LATS2
MAPT
MCM6
MCM7
MCPH1
MDM4
PIGM
PRKAA1
PRKDC
RAD23A
RAD51
RB1
RELA
SMAD4
TIMELESS
TLK1
TOPBP1
TP53
TP53BP1
UBA1
UBA2
UBB
UBE2T
USP3
USP7
XIAP
XPO1
XRCC6
YWHAG
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58 interacting genes:
AKT1
APP
ARF1
ATM
BECN1
CAPN7
CASP3
CBLC
CD160
CD44
CDK1
CDK4
CDKN2A
CDKN2B
CHEK1
CHEK2
CSNK1A1
E2F1
EP300
EPHA2
FGFR4
GLIS2
HGF
LATS2
LRSAM1
MAGEA1
MAP2K5
MDM2
MKRN3
MNAT1
NF2
PELI1
PRKAA1
RAD54B
RB1
RNF115
S100B
SFN
SMAD3
SMAD4
SMARCA2
TP53
TP63
TP73
TRIM46
TRIM55
UBC
UBE2D1
UBE2D2
UBE2D3
USP7
YWHAB
YWHAE
YWHAG
YWHAH
YWHAQ
YWHAZ
ZKSCAN4
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Entrez ID |
1111 |
4194 |
HPRD ID |
04356 |
04082 |
Ensembl ID |
ENSG00000149554
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ENSG00000198625
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Uniprot IDs |
B4DT73
E7EPP6
O14757
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A0A087WTR9
A0A087WUE3
A0A087WZ58
O15151
Q59FS6
Q68DC0
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PDB IDs |
1IA8
1NVQ
1NVR
1NVS
1ZLT
1ZYS
2AYP
2BR1
2BRB
2BRG
2BRH
2BRM
2BRN
2BRO
2C3J
2C3K
2C3L
2CGU
2CGV
2CGW
2CGX
2E9N
2E9O
2E9P
2E9U
2E9V
2GDO
2GHG
2HOG
2HXL
2HXQ
2HY0
2QHM
2QHN
2R0U
2WMQ
2WMR
2WMS
2WMT
2WMU
2WMV
2WMW
2WMX
2X8D
2X8E
2X8I
2XEY
2XEZ
2XF0
2YDI
2YDJ
2YDK
2YER
2YEX
2YM3
2YM4
2YM5
2YM6
2YM7
2YM8
2YWP
3F9N
3JVR
3JVS
3NLB
3OT3
3OT8
3PA3
3PA4
3PA5
3TKH
3TKI
3U9N
4FSM
4FSN
4FSQ
4FSR
4FST
4FSU
4FSW
4FSY
4FSZ
4FT0
4FT3
4FT5
4FT7
4FT9
4FTA
4FTC
4FTI
4FTJ
4FTK
4FTL
4FTM
4FTN
4FTO
4FTQ
4FTR
4FTT
4FTU
4GH2
4HYH
4HYI
4JIK
4QYE
4QYF
4QYG
4QYH
4RVK
4RVL
4RVM
5DLS
5F4N
5OOP
5OOR
5OOT
5OP2
5OP4
5OP5
5OP7
5OPB
5OPR
5OPS
5OPU
5OPV
5OQ5
5OQ6
5OQ7
5OQ8
5WI2
6FC8
6FCF
6FCK
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2CR8
2MWY
2N06
2N0U
2N0W
2N14
2VJE
2VJF
2VYR
3DAB
3EQY
3FDO
3FE7
3FEA
3JZO
3JZP
3JZQ
3LBJ
3MQR
3U15
4RXZ
5MNJ
5UML
5VK1
6Q9Q
6Q9S
6Q9U
6Q9W
6Q9Y
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Enriched GO Terms of Interacting Partners? |
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Tagcloud ? |
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Tagcloud (Difference) ? |
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Tagcloud (Intersection) ? |
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