GTF2A1L and SIX6

Number of citations of the paper that reports this interaction (PubMedID 20211142)
329

Data Source:
BioGRID (two hybrid)

		GTF2A1L	SIX6
Description		general transcription factor IIA subunit 1 like	SIX homeobox 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Transcription Factor TFIIA Complex Cytoplasm	Nuclear Chromatin Nucleus Transcription Factor Complex
	Molecular Function	DNA Binding Transcription Coactivator Activity Protein Binding	Transcription Regulatory Region Sequence-specific DNA Binding RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific
	Biological Process	Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Cognition Positive Regulation Of Nucleic Acid-templated Transcription	Eye Development Regulation Of Transcription By RNA Polymerase II Visual Perception Animal Organ Morphogenesis Negative Regulation Of Transcription, DNA-templated Anatomical Structure Development
Pathways
Drugs
Diseases			Anophthalmia and microphthalmia (A/M)
GWAS		Hepcidin/ferritin ratio ( 27846281) Joint mobility (Beighton score) ( 27182965) Laterality in neovascular age-related macular degeneration ( 28775256) Polycystic ovary syndrome ( 21151128)	Exhaled carbon monoxide levels in smokers with chronic obstructive pulmonary disease ( 29631575) Glaucoma ( 30054594) Glaucoma (primary open-angle) ( 22419738 29891935 25173105 29452408 22570617) Gut microbiota (bacterial taxa) ( 27723756) Height ( 20881960 25429064) Medication use (antiglaucoma preparations and miotics) ( 31015401) Menarche (age at onset) ( 25231870) Optic cup area ( 25631615 31798171 28073927) Optic disc area ( 25631615 31798171 28073927) Refractive error ( 23396134) Spherical equivalent (joint analysis main effects and education interaction) ( 27020472) Urinary sodium excretion ( 31409800) Vertical cup-disc ratio ( 31798171 25241763 28073927)
Interacting Genes		25 interacting genes: ASCL3 ATF4 CEBPE CSNK2A1 CSNK2A2 EMX1 EMX2 GAB1 GTF2A2 HMG20A HOXA5 HOXC11 HOXC9 ID3 MAFF MAFG NKX2-3 PAX9 RBFOX2 SIX6 SUB1 TBP TLX2 TLX3 ZBTB3	3 interacting genes: GTF2A1L TLE1 TLE5
Entrez ID		11036	4990
HPRD ID		05640	07557
Ensembl ID		ENSG00000242441	ENSG00000184302
Uniprot IDs		A0A140VKA3 Q9UNN4	O95475 Q6P051
PDB IDs
Enriched GO Terms of Interacting Partners?
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