LILRB4 and INPP5D

Number of citations of the paper that reports this interaction (PubMedID 9422771)
4

Data Source:
HPRD (in vitro)

		LILRB4	INPP5D
Description		leukocyte immunoglobulin like receptor B4	inositol polyphosphate-5-phosphatase D
Image
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Extracellular Exosome	Cytosol Cytoskeleton Plasma Membrane Membrane Raft
	Molecular Function	Antigen Binding Protein Binding Signaling Receptor Activity	Phosphatidylinositol-4,5-bisphosphate 5-phosphatase Activity Inositol-polyphosphate 5-phosphatase Activity Protein Binding Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity SH3 Domain Binding Inositol-1,4,5-trisphosphate 5-phosphatase Activity Inositol-1,3,4,5-tetrakisphosphate 5-phosphatase Activity
	Biological Process	Adaptive Immune Response Signal Transduction Positive Regulation Of Regulatory T Cell Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of T Cell Receptor Signaling Pathway Negative Regulation Of Protein Localization To Nucleus Negative Regulation Of Pri-miRNA Transcription By RNA Polymerase II	Phosphatidylinositol Biosynthetic Process Phosphate-containing Compound Metabolic Process Apoptotic Process Signal Transduction Determination Of Adult Lifespan Negative Regulation Of Signal Transduction Immunoglobulin Mediated Immune Response Cytokine-mediated Signaling Pathway Negative Regulation Of B Cell Proliferation Intracellular Signal Transduction Positive Regulation Of Apoptotic Process Inositol Phosphate Metabolic Process Negative Regulation Of Interleukin-6 Biosynthetic Process Positive Regulation Of B Cell Differentiation Positive Regulation Of Erythrocyte Differentiation Negative Regulation Of Monocyte Differentiation Negative Regulation Of Neutrophil Differentiation Negative Regulation Of Osteoclast Differentiation Negative Regulation Of Bone Resorption Phosphatidylinositol Dephosphorylation Negative Regulation Of Immune Response T Cell Receptor Signaling Pathway Leukocyte Migration
Pathways		Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell	Synthesis of PIPs at the plasma membrane Synthesis of IP3 and IP4 in the cytosol Downstream TCR signaling PECAM1 interactions Interleukin receptor SHC signaling
Drugs
Diseases
GWAS		Blood protein levels ( 28240269) Clozapine-induced agranulocytosis ( 25187353) Inflammatory bowel disease ( 23128233) Response to platinum-based chemotherapy (carboplatin) ( 21844884)	Allergic disease (asthma, hay fever or eczema) ( 29083406) Alzheimer's disease (late onset) ( 30617256 24162737) Alzheimer's disease or family history of Alzheimer's disease ( 30617256) Contrast sensitivity ( 24152035) Crohn's disease ( 22412388 23128233) Eosinophil counts ( 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) Family history of Alzheimer's disease ( 30617256) Neutrophil percentage of granulocytes ( 27863252) Perceived unattractiveness to mosquitoes ( 28199695) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Sum eosinophil basophil counts ( 27863252)
Interacting Genes		3 interacting genes: INPP5D PTPN11 PTPN6	42 interacting genes: ARAP1 CD22 CD300LF CRKL CSF1R CSF3R DAB1 DAB2 DOK1 DOK2 DOK3 EPOR FCGR1B FCGR2B FGR FLT3 GAB1 GAB2 GRB2 HCK IL4R JAK1 JAK3 KHDRBS3 KIT KRT31 KRT40 KRTAP10-3 KRTAP10-7 KRTAP10-9 LILRB4 LYN MET NOTCH2NLA PECAM1 PLCG1 PTPN11 SH3KBP1 SHC1 SLAMF1 XIAP ZDHHC17
Entrez ID		11006	3635
HPRD ID		11996	09033
Ensembl ID		ENSG00000186818	ENSG00000168918
Uniprot IDs		A0A0A0MSZ8 Q8NHJ6	Q92835
PDB IDs		3P2T 6K7O	2YSX 6IBD
Enriched GO Terms of Interacting Partners?
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