CCNI and IL1RAP

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		CCNI	IL1RAP
Description		cyclin I	interleukin 1 receptor accessory protein
Image		No pdb structure
GO Annotations	Cellular Component	Cyclin-dependent Protein Kinase Holoenzyme Complex Nucleus Cytoplasm	Extracellular Region Plasma Membrane Integral Component Of Plasma Membrane Membrane Glutamatergic Synapse
	Molecular Function	Protein Kinase Activity Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Kinase Binding	Interleukin-33 Receptor Activity Interleukin-1 Receptor Activity Interleukin-1 Receptor Binding NAD(P)+ Nucleosidase Activity NAD+ Nucleotidase, Cyclic ADP-ribose Generating
	Biological Process	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Protein Phosphorylation Spermatogenesis Mitotic Cell Cycle Phase Transition	Inflammatory Response Immune Response Cytokine-mediated Signaling Pathway Positive Regulation Of Interleukin-13 Production Positive Regulation Of Interleukin-5 Production Interleukin-33-mediated Signaling Pathway Interleukin-2 Biosynthetic Process Innate Immune Response Positive Regulation Of NF-kappaB Transcription Factor Activity Positive Regulation Of Synapse Assembly Protein-containing Complex Assembly Interleukin-1-mediated Signaling Pathway Interleukin-4 Secretion Regulation Of Postsynaptic Density Assembly Trans-synaptic Signaling By Trans-synaptic Complex Synaptic Membrane Adhesion Regulation Of Presynapse Assembly Positive Regulation Of Interleukin-6 Secretion
Pathways
Drugs
Diseases
GWAS			Blood protein levels ( 30072576 29875488 28240269) Longitudinal change in brain amyloid plaque burden ( 26268530) Lung cancer ( 18385676) Waist circumference ( 20966902)
Interacting Genes		5 interacting genes: AKT1 CDC25A CEP63 IL1RAP KRT18	21 interacting genes: AP2M1 CCNI IL18R1 IL1A IL1B IL1R1 IL1R2 IRAK1 KPNA1 MARCHF8 MC4R MYD88 PIK3R1 PRKCI PRPF40A PTPRD RAC1 SIRPA STAT3 TICAM2 TOLLIP
Entrez ID		10983	3556
HPRD ID		16690	04021
Ensembl ID		ENSG00000118816	ENSG00000196083
Uniprot IDs		A0A024RDH0 Q14094	A8K6K4 Q9NPH3
PDB IDs			3O4O 4DEP
Enriched GO Terms of Interacting Partners?
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