LMAN2 and FRAT1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		LMAN2	FRAT1
Description		lectin, mannose binding 2	FRAT regulator of WNT signaling pathway 1
Image		No pdb structure
GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Endoplasmic Reticulum Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Golgi Apparatus Integral Component Of Plasma Membrane Cell Surface COPII-coated ER To Golgi Transport Vesicle Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome	Cytoplasm Cytosol Intracellular Membrane-bounded Organelle
	Molecular Function	Protein Binding Mannose Binding Carbohydrate Binding Heat Shock Protein Binding Metal Ion Binding	Protein Binding
	Biological Process	ER To Golgi Vesicle-mediated Transport Retrograde Vesicle-mediated Transport, Golgi To ER Endoplasmic Reticulum Organization Golgi Organization Protein Transport Positive Regulation Of Phagocytosis	Canonical Wnt Signaling Pathway Positive Regulation Of Canonical Wnt Signaling Pathway Beta-catenin Destruction Complex Disassembly
Pathways		COPII-mediated vesicle transport Cargo concentration in the ER	Beta-catenin phosphorylation cascade Disassembly of the destruction complex and recruitment of AXIN to the membrane
Drugs
Diseases
GWAS		Activated partial thromboplastin time ( 22703881) Allergic disease (asthma, hay fever or eczema) ( 29083406) Anthropometric traits ( 30166351) Anthropometric traits (multi-trait analysis) ( 30166351) Blood protein levels ( 30072576) Chronic kidney disease ( 20383146) Metabolite levels (small molecules and protein measures) ( 27005778) Red blood cell count ( 27863252) Serum uric acid levels ( 30993211) Urinary calcium excretion ( 31993563) Waist-to-hip ratio adjusted for BMI ( 26426971) Waist-to-hip ratio adjusted for BMI (age <50) ( 26426971) Waist-to-hip ratio adjusted for BMI x sex x age interaction (4df test) ( 26426971)
Interacting Genes		5 interacting genes: ATP13A2 FRAT1 MAPK9 SUPT5H TSPAN17	13 interacting genes: DVL1 GPRASP2 GRN GSK3B KCNK5 KRT18 LAMC3 LMAN2 LTBP4 PLSCR1 PSMA3 RABEP2 TDRD7
Entrez ID		10960	10023
HPRD ID		17285	03935
Ensembl ID		ENSG00000169223	ENSG00000165879
Uniprot IDs		A0A384NPY7 Q12907	Q92837
PDB IDs			1GNG 3ZRK 3ZRL 3ZRM 4AFJ 5OY4
Enriched GO Terms of Interacting Partners?
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