EDAR and EDARADD

Number of citations of the paper that reports this interaction (PubMedID 11882293)
16

Data Source:
HPRD (in vitro)

		EDAR	EDARADD
Description		ectodysplasin A receptor	EDAR associated death domain
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Membrane Apical Part Of Cell	Cytosol
	Molecular Function	Transmembrane Signaling Receptor Activity Protein Binding Signaling Receptor Activity	Protein Binding
	Biological Process	Hair Follicle Development Apoptotic Process Epidermis Development Positive Regulation Of Gene Expression Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Odontogenesis Of Dentin-containing Tooth Positive Regulation Of I-kappaB Kinase/NF-kappaB Signaling Pigmentation Positive Regulation Of JNK Cascade Salivary Gland Cavitation Positive Regulation Of NIK/NF-kappaB Signaling	Multicellular Organism Development Cell Differentiation Tumor Necrosis Factor-mediated Signaling Pathway Positive Regulation Of NIK/NF-kappaB Signaling
Pathways		TNFs bind their physiological receptors	TNFs bind their physiological receptors
Drugs
Diseases		Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic	Ectodermal dysplasia, including: Ectodermal dysplasia, anhidrotic; Ectodermal dysplasia, hypohidrotic
GWAS		Beard thickness ( 26926045) Blood protein levels ( 30072576 29875488 28240269) Cleft lip with or without cleft palate (maternal periconceptional alcohol intake interaction) ( 29535761) Ear morphology ( 26105758) Ear protrusion ( 26105758) Eyebrow thickness ( 30248107) Helix rolling ( 26105758) Lobe attachment ( 26105758) Lobe attachment (rater scored) ( 29198719) Lobe size ( 26105758) lower facial morphology traits (quantitative measurement) ( 27193062) Lung function (FVC) ( 30061609) Male-pattern baldness ( 27182965) Monobrow ( 27182965) Monobrow thickness ( 26926045) Scalp hair shape ( 26926045) Straight vs curly hair ( 27487801 29895819) Thick vs thin eyebrows ( 29895819)	Urate levels (BMI interaction) ( 25811787)
Interacting Genes		6 interacting genes: EDA EDARADD MAP3K14 TRAF1 TRAF2 TRAF3	10 interacting genes: EDAR NTAQ1 RNF111 SDCBP SHPRH SUMO1 SUMO1P1 TRAF2 TRAF6 UBE2I
Entrez ID		10913	128178
HPRD ID		04974	05965
Ensembl ID		ENSG00000135960	ENSG00000186197
Uniprot IDs		Q9UNE0	Q8WWZ3
PDB IDs
Enriched GO Terms of Interacting Partners?
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