RUVBL2 and FDFT1

Number of citations of the paper that reports this interaction (PubMedID 16169070)
820

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		RUVBL2	FDFT1
Description		RuvB like AAA ATPase 2	farnesyl-diphosphate farnesyltransferase 1
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GO Annotations	Cellular Component	Swr1 Complex Intracellular Nucleus Nucleoplasm Nuclear Euchromatin Cytoplasm Centrosome Cytosol Membrane Nuclear Matrix Ino80 Complex NuA4 Histone Acetyltransferase Complex Extracellular Exosome MLL1 Complex R2TP Complex Ribonucleoprotein Complex	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Integral Component Of Membrane
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding TFIID-class Transcription Factor Complex Binding DNA Helicase Activity Transcription Corepressor Activity Protein Binding ATP Binding Beta-catenin Binding ATPase Activity TBP-class Protein Binding Chromatin DNA Binding Identical Protein Binding Protein Homodimerization Activity 5'-3' DNA Helicase Activity ADP Binding Unfolded Protein Binding ATPase Binding	Farnesyl-diphosphate Farnesyltransferase Activity Protein Binding Metal Ion Binding Squalene Synthase Activity
	Biological Process	Box C/D SnoRNP Assembly DNA Repair DNA Recombination Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Protein Folding Histone Acetylation DNA Duplex Unwinding Cellular Response To UV Positive Regulation Of Histone Acetylation Regulation Of Growth Histone H4 Acetylation Histone H2A Acetylation Positive Regulation Of Transcription By RNA Polymerase II Establishment Of Protein Localization To Chromatin Cellular Response To Estradiol Stimulus Transcriptional Activation By Promoter-enhancer Looping Negative Regulation Of Estrogen Receptor Binding Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Nucleic Acid-templated Transcription Positive Regulation Of Telomerase RNA Localization To Cajal Body	Steroid Biosynthetic Process Cholesterol Biosynthetic Process Ergosterol Biosynthetic Process Regulation Of Lipid Metabolic Process Farnesyl Diphosphate Metabolic Process Regulation Of Cholesterol Biosynthetic Process
Pathways		Telomere Extension By Telomerase HATs acetylate histones	Cholesterol biosynthesis PPARA activates gene expression Activation of gene expression by SREBF (SREBP)
Drugs		Quercetin	TAK-475
Diseases
GWAS		Blood protein levels ( 28240269)	Blood protein levels ( 28240269) C-reactive protein levels ( 30388399) Ejection fraction in Tripanosoma cruzi seropositivity ( 24324551) General factor of neuroticism ( 30867560) Heschl's gyrus morphology ( 25130324) Metabolite levels ( 23823483) Non-alcoholic fatty liver disease histology (lobular) ( 20708005) Non-alcoholic fatty liver disease histology (other) ( 20708005) Polycystic ovary syndrome ( 26284813)
Interacting Genes		30 interacting genes: AGR2 APP APPL1 APPL2 ATF2 BCL3 CCDC103 CDKN2A CTNNB1 DPCD EHMT2 EP300 EXOSC10 FBL FDFT1 HDAC1 HDAC4 LIG4 LNX1 MCPH1 MDM2 MYC NDRG1 RUVBL1 STOM TAF9 TBP TERT YWHAQ YY1	8 interacting genes: ANXA5 ARL6IP1 CREB3 LMNA RFLNA RUVBL2 SHPRH TMEM43
Entrez ID		10856	2222
HPRD ID		16070	01694
Ensembl ID		ENSG00000183207	ENSG00000079459
Uniprot IDs		B3KNL2 Q9Y230	A0A1W2PQ47 B4DND3 B4DWP0 B7Z9R8 P37268 Q6IAX1
PDB IDs		2CQA 2XSZ 3UK6 5OAF 6FO1 6H7X 6HTS 6IGM 6QI8 6QI9	1EZF 3ASX 3LEE 3Q2Z 3Q30 3V66 3VJ8 3VJ9 3VJA 3VJB 3VJC 3WC9 3WCD 3WCF 3WCH 3WCI 3WCJ 3WCL 3WCM 3WEF 3WEG 3WEH 3WEI 3WEJ 3WEK 3WSA
Enriched GO Terms of Interacting Partners?
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