IQGAP2 and ACTR2

Number of citations of the paper that reports this interaction (PubMedID 12515716)
21

Data Source:
HPRD (in vivo)

		IQGAP2	ACTR2
Description		IQ motif containing GTPase activating protein 2	actin related protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Microvillus Cell Surface Actin Cytoskeleton Lamellipodium Filopodium Secretory Granule Membrane Extracellular Exosome	Extracellular Region Cell Nucleus Cytoplasm Cytosol Arp2/3 Protein Complex Focal Adhesion Postsynaptic Density Actin Cytoskeleton Membrane Lamellipodium Actin Cap Actin Cortical Patch Azurophil Granule Lumen Site Of Double-strand Break Podosome Core Extracellular Exosome Invadopodium Ficolin-1-rich Granule Lumen
	Molecular Function	Actin Binding GTPase Inhibitor Activity Calmodulin Binding Phosphatidylinositol-3,4,5-trisphosphate Binding Rho GTPase Binding Rac GTPase Binding Actin Filament Binding Arp2/3 Complex Binding	Structural Constituent Of Cytoskeleton ATP Binding Actin Filament Binding
	Biological Process	Signal Transduction Negative Regulation Of GTPase Activity Arp2/3 Complex-mediated Actin Nucleation Neutrophil Degranulation Thrombin-activated Receptor Signaling Pathway	Establishment Or Maintenance Of Cell Polarity Associative Learning Asymmetric Cell Division Meiotic Chromosome Movement Towards Spindle Pole Cytosolic Transport Meiotic Cytokinesis Arp2/3 Complex-mediated Actin Nucleation Response To Immobilization Stress Cellular Response To Trichostatin A Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Neutrophil Degranulation Response To Ethanol Positive Regulation Of Transcription By RNA Polymerase II Ephrin Receptor Signaling Pathway Spindle Localization Cilium Assembly Positive Regulation Of Dendritic Spine Morphogenesis Membrane Organization Cellular Response To Interferon-gamma Positive Regulation Of Double-strand Break Repair Via Homologous Recombination Regulation Of Double-strand Break Repair Via Nonhomologous End Joining
Pathways		RHO GTPases activate IQGAPs Neutrophil degranulation	Regulation of actin dynamics for phagocytic cup formation Regulation of actin dynamics for phagocytic cup formation EPHB-mediated forward signaling RHO GTPases Activate WASPs and WAVEs RHO GTPases Activate WASPs and WAVEs Neutrophil degranulation Clathrin-mediated endocytosis FCGR3A-mediated phagocytosis FCGR3A-mediated phagocytosis
Drugs			N-[2-(2-methyl-1H-indol-3-yl)ethyl]thiophene-2-carboxamide (2S)-2-(3-bromophenyl)-3-(5-chloro-2-hydroxyphenyl)-1,3-thiazolidin-4-one
Diseases
GWAS		Dental caries (decayed, missing and filled teeth) ( 31533690) Dental caries (decayed, missing and filled tooth surfaces) ( 31533690) Hearing impairment ( 20068591) High light scatter reticulocyte count ( 27863252) Late-onset Alzheimer's disease ( 27770636) Mean platelet volume ( 27863252) Phenylephrine infusion rate during anesthesia ( 31455332) Platelet count ( 27863252) Platelet distribution width ( 27863252) Reticulocyte count ( 27863252) Reticulocyte fraction of red cells ( 27863252) Thiazide-induced adverse metabolic effects in hypertensive patients ( 23400010) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683) Waist-to-hip ratio adjusted for BMI x sex interaction ( 26426971)	Coronary artery disease ( 29212778) Heel bone mineral density ( 30598549) Lung adenocarcinoma ( 28604730) Lung cancer ( 28604730) Metabolite levels ( 23823483)
Interacting Genes		6 interacting genes: ACTR2 ALG8 CALM1 CDC42 RAC1 RHOG	13 interacting genes: ACTC1 ACTR3 ARPC1B ARPC4 ARPC5 BMP2 ELF5 HCLS1 IQGAP2 SHARPIN WASF1 WASF2 WASL
Entrez ID		10788	10097
HPRD ID		09253	05023
Ensembl ID		ENSG00000145703	ENSG00000138071
Uniprot IDs		B7Z7U6 B7Z7X2 Q13576 Q59HA3	P61160
PDB IDs		3IEZ 4EZA 5CJP
Enriched GO Terms of Interacting Partners?
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