AHCYL1 and CDKN2C

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid, two hybrid)

		AHCYL1	CDKN2C
Description		adenosylhomocysteinase like 1	cyclin dependent kinase inhibitor 2C
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GO Annotations	Cellular Component	Cytoplasm Endoplasmic Reticulum Membrane Cytosol Apical Plasma Membrane Extracellular Exosome	Nucleus Cytoplasm Cytosol
	Molecular Function	RNA Binding Adenosylhomocysteinase Activity Protein Binding Identical Protein Binding	Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding
	Biological Process	MRNA Polyadenylation Protein Export From Nucleus One-carbon Metabolic Process Positive Regulation Of Sodium Ion Transport Regulation Of MRNA 3'-end Processing Regulation Of Ion Transmembrane Transporter Activity S-adenosylmethionine Cycle Angiotensin-activated Signaling Pathway Epithelial Fluid Transport Regulation Of Anion Transport Response To Calcium Ion Regulation Of Cardiac Conduction	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Cell Cycle Arrest Negative Regulation Of Cell Proliferation Negative Regulation Of Cell Growth Negative Regulation Of Phosphorylation Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Oligodendrocyte Differentiation Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		PLC beta mediated events DAG and IP3 signaling Role of phospholipids in phagocytosis FCERI mediated Ca+2 mobilization Regulation of insulin secretion VEGFR2 mediated cell proliferation Ion homeostasis Ion homeostasis CLEC7A (Dectin-1) induces NFAT activation FCGR3A-mediated IL10 synthesis Antigen activates B Cell Receptor (BCR) leading to generation of second messengers	Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) Oncogene Induced Senescence Cyclin D associated events in G1
Drugs
Diseases
GWAS		Height ( 31562340)	Atrial fibrillation ( 29290336) Height ( 31562340) Hippocampal tail volume (corrected for total hippocampal volume) ( 30279459) Ischemic stroke (large artery atherosclerosis) ( 26732560) Male-pattern baldness ( 28196072) Pulse pressure ( 30578418) QRS complex (12-leadsum) ( 27659466) QRS duration ( 27577874 21076409 27659466) Ventricular ectopy ( 29618737) Ventricular ectopy or supraventricular ectopy (pleiotropy) ( 29618737)
Interacting Genes		17 interacting genes: BID CDKN2C DACH1 GEM HGS ITPR1 LRRK2 MEOX2 MFHAS1 PPL PSMD9 RNF6 SLC23A1 SOX30 SRPK1 SRPK2 ZNF165	51 interacting genes: AHCYL1 AKT1 ANGPTL4 APLP1 ARNT ATM ATR CCDC90B CCND2 CCNE1 CDK4 CDK6 CDKN2A CDKN2B COPS6 DRAP1 EPHA2 ERBB2 FGFR4 GDF9 GOPC GREB1 GRM1 LATS2 LNX2 LRIF1 LY96 MAP2K3 MAP2K5 MAPK10 MAPK8 MTA3 MYC NAGK NAT2 NF2 NIF3L1 PDGFRA PPP2CA RAF1 RBM48 REL SCGB2A2 SNU13 ST14 STK11 TCF12 TCF4 TLE1 TP53 UNC119
Entrez ID		10768	1031
HPRD ID		07613	04534
Ensembl ID		ENSG00000168710	ENSG00000123080
Uniprot IDs		A0A024R0A8 O43865	P42773 Q6ICV4
PDB IDs		3MTG	1BU9 1G3N 1IHB 1MX2 1MX4 1MX6
Enriched GO Terms of Interacting Partners?
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