CTCF and SUZ12

Number of citations of the paper that reports this interaction (PubMedID 18662993)
95

Data Source:
BioGRID (affinity chromatography technology, pull down, two hybrid, pull down)

		CTCF	SUZ12
Description		CCCTC-binding factor	SUZ12 polycomb repressive complex 2 subunit
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GO Annotations	Cellular Component	Chromosome, Centromeric Region Condensed Chromosome Nucleus Nucleoplasm Nucleolus	Sex Chromatin Nucleus Nucleoplasm Nucleolus RSC-type Complex Nuclear Body Protein-DNA Complex ESC/E(Z) Complex
	Molecular Function	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA-binding Transcription Factor Activity Transcription Corepressor Activity Protein Binding Zinc Ion Binding Chromatin Insulator Sequence Binding Sequence-specific DNA Binding Transcription Regulatory Region DNA Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding RNA Binding Protein Binding Chromatin DNA Binding Methylated Histone Binding Histone Methyltransferase Activity Metal Ion Binding Histone Methyltransferase Activity (H3-K27 Specific) Promoter-specific Chromatin Binding
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II DNA Methylation Regulation Of Gene Expression By Genetic Imprinting Chromosome Segregation Negative Regulation Of Cell Proliferation Maintenance Of DNA Methylation Positive Regulation Of Gene Expression Nucleosome Positioning Regulation Of Histone Methylation Regulation Of Histone Acetylation Regulation Of Gene Expression, Epigenetic Regulation Of Molecular Function, Epigenetic Negative Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription, DNA-templated Positive Regulation Of Transcription By RNA Polymerase II Regulation Of Centromeric Sister Chromatid Cohesion Protein Localization To Chromosome, Centromeric Region	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Transcription, DNA-templated Positive Regulation Of Cell Proliferation Histone Ubiquitination Negative Regulation Of Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Oligodendrocyte Differentiation Negative Regulation Of G0 To G1 Transition Histone H3-K27 Methylation
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	PRC2 methylates histones and DNA Oxidative Stress Induced Senescence PKMTs methylate histone lysines SUMOylation of chromatin organization proteins Activation of anterior HOX genes in hindbrain development during early embryogenesis Regulation of PTEN gene transcription Regulation of PTEN gene transcription Transcriptional Regulation by E2F6 HCMV Early Events
Drugs
Diseases
GWAS		Elevated fasting plasma glucose ( 30004843) HDL cholesterol ( 19060911)	High chromosomal aberration frequency (chromosome type) ( 31586183) Hip circumference adjusted for BMI ( 25673412)
Interacting Genes		19 interacting genes: CHD1L CHD7 CHD8 HMGB1 MT-ND4 PARP1 POLR2A RAD51 RALA RHOU RXRA SIN3A SMAD3 SMAD4 SUZ12 THRB TRB YBX1 ZMYM4	17 interacting genes: AEBP2 BCL11A CDK19 CDK8 CREB1 CTCF EZH2 H1-1 H3-4 LATS2 MED17 MED6 PAXIP1 PJA1 PRDM14 UBE2I WDR77
Entrez ID		10664	23512
HPRD ID		05005	06949
Ensembl ID		ENSG00000102974	ENSG00000178691
Uniprot IDs		A0A2R8YFL0 P49711	J3QQW9 Q15022
PDB IDs		1X6H 2CT1 5K5H 5K5I 5K5J 5K5L 5KKQ 5T00 5T0U 5UND 5YEF 5YEG 5YEH 5YEL	4W2R 5HYN 5IJ7 5IJ8 5LS6 5WAI 5WAK 5WG6 6B3W 6C23 6C24
Enriched GO Terms of Interacting Partners?
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