CENPE and SEPTIN7

Number of citations of the paper that reports this interaction (PubMedID 19779646)
3

Data Source:
BioGRID (two hybrid)

		CENPE	SEPTIN7
Description		centromere protein E	septin 7
Image
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Chromosome, Centromeric Region Cell Nucleus Nucleoplasm Chromosome Kinetochore Microtubule Cytosol Kinesin Complex Microtubule Microtubule Cytoskeleton Membrane Midbody Spindle Midzone Mitotic Spindle Midzone	Condensed Chromosome Kinetochore Stress Fiber Nucleus Spindle Cytosol Axoneme Septin Ring Microtubule Cytoskeleton Apical Plasma Membrane Midbody Septin Complex Cell Division Site Cleavage Furrow Extracellular Exosome Sperm Annulus Non-motile Cilium
	Molecular Function	Microtubule Motor Activity Protein Binding ATP Binding Microtubule Binding ATPase Activity Kinetochore Binding	GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Cadherin Binding Molecular Adaptor Activity
	Biological Process	Mitotic Cell Cycle Retrograde Vesicle-mediated Transport, Golgi To ER Microtubule-based Movement Mitotic Spindle Organization Chromosome Segregation Mitotic Chromosome Movement Towards Spindle Pole Mitotic Metaphase Plate Congression Multicellular Organism Development Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Protein Kinase Activity Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Assembly Microtubule Plus-end Directed Mitotic Chromosome Migration Lateral Attachment Of Mitotic Spindle Microtubules To Kinetochore	Spermatogenesis Regulation Of Embryonic Cell Shape Cell Differentiation Negative Regulation Of Cell Migration Cellular Protein Localization Positive Regulation Of Apoptotic Process Cilium Assembly Cytoskeleton-dependent Cytokinesis Positive Regulation Of Non-motile Cilium Assembly Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal MHC class II antigen presentation Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins COPI-dependent Golgi-to-ER retrograde traffic Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation Kinesins	MAPK6/MAPK4 signaling
Drugs		GSK-923295
Diseases
GWAS		Chlamydia trachomatis seropositivity ( 29967566) Schizophrenia ( 28991256) Spontaneous preterm birth without premature rupture of membranes ( 31194736) Testicular germ cell tumor ( 25877299 28604728 28604732 23666240)
Interacting Genes		11 interacting genes: BUB1B CENPF CLK1 CUL1 DNAJB1 FANCA NUF2 SEPTIN7 SKP1 TRAF4 UBC	12 interacting genes: ANLN CDC42EP2 CDC42EP3 CDC42EP5 CENPE HDAC6 REL S100A4 SEPTIN10 SEPTIN11 SEPTIN5 SEPTIN9
Entrez ID		1062	989
HPRD ID		00316	04398
Ensembl ID		ENSG00000138778	ENSG00000122545
Uniprot IDs		Q02224	A0A023T695 A0A024RA87 A8K3D0 B4DNE4 G3V1Q4 Q16181
PDB IDs		1T5C 5JVP	2QAG 3T5D 3TW4 6N0B 6N12
Enriched GO Terms of Interacting Partners?
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