NPC2 and CTSW

		NPC2	CTSW
Description		NPC intracellular cholesterol transporter 2	cathepsin W
Image			No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Azurophil Granule Lumen Lysosomal Lumen Extracellular Exosome	Extracellular Region Extracellular Space Lysosome Endoplasmic Reticulum Membrane Platelet Dense Granule Lumen
	Molecular Function	Protein Binding Cholesterol Binding Enzyme Binding Sterol Binding Intermembrane Cholesterol Transfer Activity	Cysteine-type Endopeptidase Activity Cysteine-type Peptidase Activity
	Biological Process	Cholesterol Metabolic Process Response To Virus Phospholipid Transport Sterol Transport Regulation Of Isoprenoid Metabolic Process Cholesterol Transport Intracellular Sterol Transport Intracellular Cholesterol Transport Cholesterol Efflux Low-density Lipoprotein Particle Clearance Cholesterol Homeostasis Neutrophil Degranulation Glycolipid Transport	Platelet Degranulation Immune Response Proteolysis Involved In Cellular Protein Catabolic Process
Pathways		Neutrophil degranulation LDL clearance	Platelet degranulation
Drugs
Diseases		Niemann-Pick type C disease (NPC), including: Niemann-Pick disease, type C1; Niemann-Pick disease, type C2
GWAS		Advanced glycation end-product levels ( 26915486) Blood protein levels ( 29875488) Intraocular pressure ( 31959993)	Acne (severe) ( 24927181) Inflammatory bowel disease ( 23128233)
Interacting Genes		19 interacting genes: AREL1 BARD1 BRCA1 CTSW DHDDS ECT2 EIF2B2 EOLA1 ERRFI1 LIG4 PAXIP1 PDIA6 SCNN1A SCRN1 SSR1 TMED10 TRIM14 USP4 VASH1	2 interacting genes: CREB3 NPC2
Entrez ID		10577	1521
HPRD ID		03008	03840
Ensembl ID		ENSG00000119655	ENSG00000172543
Uniprot IDs		A0A024R6C0 P61916	P56202
PDB IDs		5KWY
Enriched GO Terms of Interacting Partners?
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