APPBP2 and CYBA

Number of citations of the paper that reports this interaction (PubMedID 30665935)
0

Data Source:
BioGRID (two hybrid, pull down, far western blotting, affinity chromatography technology)

		APPBP2	CYBA
Description		amyloid beta precursor protein binding protein 2	cytochrome b-245 alpha chain
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Microtubule Microtubule Associated Complex Cytoplasmic Vesicle Membrane	Stress Fiber Cell Nucleus Endosome Endoplasmic Reticulum Membrane Golgi Apparatus Plasma Membrane Focal Adhesion Membrane Apical Plasma Membrane Secretory Granule Dendrite Phagocytic Vesicle Membrane Specific Granule Membrane NADPH Oxidase Complex Neuronal Cell Body Tertiary Granule Membrane Perinuclear Endoplasmic Reticulum
	Molecular Function	Microtubule Motor Activity Protein Binding	Protein Binding Electron Transfer Activity Superoxide-generating NADPH Oxidase Activity SH3 Domain Binding Heme Binding Metal Ion Binding Protein Heterodimerization Activity
	Biological Process	Intracellular Protein Transport Intracellular Transport	Response To Hypoxia Positive Regulation Of Endothelial Cell Proliferation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class I, TAP-dependent Negative Regulation Of Glomerular Filtration By Angiotensin Superoxide Metabolic Process Inflammatory Response Response To Activity Smooth Muscle Hypertrophy Cytochrome Complex Assembly Electron Transport Chain Positive Regulation Of Cell Growth Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Superoxide Anion Generation Positive Regulation Of NAD(P)H Oxidase Activity Positive Regulation Of Toll-like Receptor 2 Signaling Pathway Cellular Response To Oxidative Stress Superoxide Anion Generation Neutrophil Degranulation Innate Immune Response Cell Redox Homeostasis Respiratory Burst Vascular Endothelial Growth Factor Receptor Signaling Pathway Positive Regulation Of Smooth Muscle Cell Proliferation Hydrogen Peroxide Biosynthetic Process Positive Regulation Of Phagocytosis Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Oxidation-reduction Process Positive Regulation Of Mucus Secretion Response To Interleukin-1 Cellular Response To Mechanical Stimulus Cellular Response To Glucose Stimulus Cellular Response To Tumor Necrosis Factor Cellular Response To Organic Cyclic Compound Cellular Response To Gamma Radiation Positive Regulation Of Defense Response To Bacterium Positive Regulation Of Reactive Oxygen Species Biosynthetic Process Response To Aldosterone Cellular Response To Angiotensin Cellular Response To L-glutamine
Pathways			ROS and RNS production in phagocytes Cross-presentation of particulate exogenous antigens (phagosomes) Detoxification of Reactive Oxygen Species VEGFA-VEGFR2 Pathway RHO GTPases Activate NADPH Oxidases Neutrophil degranulation WNT5:FZD7-mediated leishmania damping
Drugs			Dextromethorphan
Diseases			Chronic granulomatous disease, including the following four diseases: X-linked CGD (gp91 phox CGD); p22phox deficiency (p22phox CGD); p47phox deficiency (p47phox CGD); p67phox deficiency (p67phox CGD)
GWAS		Waist-hip ratio ( 28552196)	Glycated hemoglobin levels ( 24647736) Hair color ( 26926045)
Interacting Genes		81 interacting genes: - AHCY AIM2 AK3 ANKRD10 APP AR ARMCX5 C1orf50 C6orf226 CALM3 CCDC85C CCNL1 CDK16 CHMP5 CIBAR1 CLCN1 CNTFR COL24A1 CORO2B CREB3 CSNK1G2 CTC1 CYBA DCD DHRS2 DPEP1 EID3 ERO1A FAM107A FSTL1 FXYD7 GALNT3 GCSAM GP9 GSTP1 H2AC15 HIPK4 HSPA4 KIF6 KLF11 KLHL35 LANCL2 LONRF3 LUC7L2 LUZP4 MFSD3 MLLT3 MUL1 NFYA NPRL3 PCSK5 PI4KAP2 PPP1R8 PRKAA2 PRKACB PYROXD2 RASSF5 RNF128 RNF34 RRS1 SELENOI SELENOV SLC22A6 SLC25A23 SNX5 ST8SIA5 SYNRG SYT11 TAF11 TAFA4 TBL3 TCF25 UBE2R2 UGGT2 WAS WDR24 WNT5B ZC3H10 ZCCHC12 ZNF747	13 interacting genes: APPBP2 CPT1A CYBB MDFI NCF1 NCF2 NCF4 NOX1 PSMA3 RAC1 RBPMS RCHY1 UPF2
Entrez ID		10513	1535
HPRD ID		05616	01989
Ensembl ID		ENSG00000062725	ENSG00000051523
Uniprot IDs		A0A024QZ47 Q92624	B4DT46 H3BNP7 P13498
PDB IDs			1WLP
Enriched GO Terms of Interacting Partners?
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