ZNHIT1 and SH2D1A

Number of citations of the paper that reports this interaction (PubMedID 25814554)
22

Data Source:
BioGRID (two hybrid)

		ZNHIT1	SH2D1A
Description		zinc finger HIT-type containing 1	SH2 domain containing 1A
Image		No pdb structure
GO Annotations	Cellular Component	Swr1 Complex Nucleus Nucleoplasm	Cytoplasm Cytosol
	Molecular Function	Protein Binding Nucleosome Binding Histone Deacetylase Binding Metal Ion Binding	SH3/SH2 Adaptor Activity Protein Binding
	Biological Process	Regulation Of Histone Deacetylation Histone Exchange	Adaptive Immune Response Humoral Immune Response Cellular Defense Response Cell-cell Signaling Positive Regulation Of Signal Transduction Innate Immune Response Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Immune Response
Pathways			Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell
Drugs
Diseases			Other well-defined immunodeficiency syndromes, including the following seven diseases: Wiskott-Aldrich syndrome; DiGeorge syndrome; Hyper-IgE syndrome; X-linked lymphoproliferative syndrome; Immunodeficiency, Polyendocrinopathy, Enteropathy, X-linked Syndrome (IPEX); Cartilage-Hair Hypoplasia; Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED)
GWAS
Interacting Genes		13 interacting genes: AKAP8 CSNK2B DAPP1 GRB7 HINFP KRTAP10-7 MAPK11 MAPK14 PMPCB RIPK1 SH2D1A TNIP1 TP53	26 interacting genes: ARHGEF6 ARHGEF7 ATF3 CCDC74A CD84 DOK1 EGFR ERBB3 FYB1 FYN GRB2 LCK LETMD1 LHX4 LY9 MAPK11 MAPK14 NCK1 NGEF OLIG1 PTK2 SLAMF1 SLAMF6 SLAMF7 TNK2 ZNHIT1
Entrez ID		10467	4068
HPRD ID		15892	02390
Ensembl ID		ENSG00000106400	ENSG00000183918
Uniprot IDs		O43257	O60880
PDB IDs			1D1Z 1D4T 1D4W 1KA6 1KA7 1M27
Enriched GO Terms of Interacting Partners?
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