NDC80 and RUFY4

Number of citations of the paper that reports this interaction (PubMedID 25416956)
381

Data Source:
BioGRID (two hybrid)

		NDC80	RUFY4
Description		NDC80 kinetochore complex component	RUN and FYVE domain containing 4
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome, Centromeric Region Kinetochore Condensed Chromosome Kinetochore Condensed Nuclear Chromosome Kinetochore Condensed Nuclear Chromosome Outer Kinetochore Cell Nucleus Nucleoplasm Centrosome Cytosol Membrane Ndc80 Complex	Autophagosome Cytoplasmic Vesicle
	Molecular Function	Protein Binding Identical Protein Binding	Protein Binding Phosphatidylinositol-3-phosphate Binding Metal Ion Binding
	Biological Process	Mitotic Sister Chromatid Segregation Establishment Of Mitotic Spindle Orientation Mitotic Cell Cycle Mitotic Spindle Organization Chromosome Segregation Attachment Of Spindle Microtubules To Kinetochore Cell Division Metaphase Plate Congression Attachment Of Mitotic Spindle Microtubules To Kinetochore Kinetochore Organization Positive Regulation Of Mitotic Cell Cycle Spindle Assembly Checkpoint Positive Regulation Of Protein Localization To Kinetochore	Autophagosome Assembly Positive Regulation Of Macroautophagy Cellular Response To Interleukin-4
Pathways		Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal Separation of Sister Chromatids Resolution of Sister Chromatid Cohesion RHO GTPases Activate Formins Mitotic Prometaphase EML4 and NUDC in mitotic spindle formation
Drugs
Diseases
GWAS		Metabolite levels ( 23823483) Response to cognitive-behavioural therapy in major depressive disorder ( 31123309)	Height ( 28552196) Inflammatory bowel disease ( 28067908) White blood cell count (basophil) ( 27863252)
Interacting Genes		46 interacting genes: AMOTL2 ATF4 ATP5PO AURKA AURKB BLOC1S6 CALCOCO1 CCHCR1 CCNH CCNK CENPH CKAP5 HAUS1 HGS IFT20 INPP1 KLC3 KLHL12 KRT6B MAD1L1 MAD2L1 MFAP1 MIS12 NDE1 NDEL1 NEK2 NUF2 PCM1 PFDN1 PSMC2 RB1 RUFY4 SFR1 SGF29 SKA1 SMC1A SPC25 STX11 TFIP11 TNIP1 TOM1L1 TP53BP2 TXLNA USHBP1 WASHC3 ZWINT	2 interacting genes: LNX1 NDC80
Entrez ID		10403	285180
HPRD ID		06277	13539
Ensembl ID		ENSG00000080986	ENSG00000188282
Uniprot IDs		A8K031 O14777	Q6ZNE9
PDB IDs		2IGP 2VE7 3IZ0
Enriched GO Terms of Interacting Partners?
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