AKR1A1 and EXOSC4

Number of citations of the paper that reports this interaction (PubMedID 15231747)
56

Data Source:
HPRD (two hybrid)

		AKR1A1	EXOSC4
Description		aldo-keto reductase family 1 member A1	exosome component 4
Image
GO Annotations	Cellular Component	Extracellular Space Cytosol Apical Plasma Membrane Synapse Extracellular Exosome	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Nucleus Nucleoplasm Nucleolus Cytoplasm Cytosol Transcriptionally Active Chromatin Intermediate Filament Cytoskeleton
	Molecular Function	Alditol:NADP+ 1-oxidoreductase Activity Aldo-keto Reductase (NADP) Activity Retinol Dehydrogenase Activity Protein Binding Alcohol Dehydrogenase (NADP+) Activity Electron Transfer Activity Oxidoreductase Activity Allyl-alcohol Dehydrogenase Activity L-glucuronate Reductase Activity Glucuronolactone Reductase Activity	3'-5'-exoribonuclease Activity Exoribonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding
	Biological Process	Glucose Metabolic Process Cellular Aldehyde Metabolic Process Glucuronate Catabolic Process To Xylulose 5-phosphate L-ascorbic Acid Biosynthetic Process Electron Transport Chain D-glucuronate Catabolic Process Daunorubicin Metabolic Process Doxorubicin Metabolic Process Aldehyde Catabolic Process Cellular Detoxification Of Aldehyde Glutathione Derivative Biosynthetic Process	Maturation Of 5.8S RRNA Nuclear-transcribed MRNA Catabolic Process RRNA Processing RRNA Catabolic Process Positive Regulation Of Cell Growth Nuclear-transcribed MRNA Catabolic Process, Exonucleolytic, 3'-5' U4 SnRNA 3'-end Processing Regulation Of MRNA Stability Exonucleolytic Nuclear-transcribed MRNA Catabolic Process Involved In Deadenylation-dependent Decay DNA Deamination Defense Response To Virus Nuclear MRNA Surveillance Histone MRNA Catabolic Process Polyadenylation-dependent SnoRNA 3'-end Processing RNA Phosphodiester Bond Hydrolysis, Exonucleolytic
Pathways		Glutathione conjugation Formation of xylulose-5-phosphate	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol
Drugs		Tolrestat 2'-Monophosphoadenosine 5'-Diphosphoribose Copper
Diseases
GWAS		Blood protein levels ( 30072576 29875488) Body mass index ( 26426971) Estimated glomerular filtration rate ( 31152163) High light scatter reticulocyte count ( 27863252) Pulse pressure ( 30224653 30578418)	Bipolar disorder ( 31043756) Bipolar I disorder ( 31043756)
Interacting Genes		3 interacting genes: EXOSC4 TERF1 TERF2IP	28 interacting genes: AKR1A1 DIS3 DXO EEF1A1 EXOSC1 EXOSC10 EXOSC2 EXOSC3 EXOSC6 EXOSC7 EXOSC8 EXOSC9 FAHD1 GADD45GIP1 GTF2IRD1 HBS1L HNRNPD LRRC8D MPP6 MPZL1 MTREX NEK1 SKIV2L SMPD4 TSEN15 UPF1 UPF2 UPF3B
Entrez ID		10327	54512
HPRD ID		00069	16221
Ensembl ID		ENSG00000117448	ENSG00000178896
Uniprot IDs		P14550 V9HWI0	Q9NPD3
PDB IDs		2ALR	2NN6 6D6Q 6D6R 6H25
Enriched GO Terms of Interacting Partners?
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?