RAD50 and RINT1

Number of citations of the paper that reports this interaction (PubMedID 11096100)
28

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vivo)

		RAD50	RINT1
Description		RAD50 double strand break repair protein	RAD50 interactor 1
Image			No pdb structure
GO Annotations	Cellular Component	Nuclear Chromosome, Telomeric Region Nuclear Chromatin Condensed Nuclear Chromosome Nucleoplasm Membrane Mre11 Complex Site Of Double-strand Break	Endoplasmic Reticulum Endoplasmic Reticulum Membrane Cytosol Dsl1/NZR Complex
	Molecular Function	Single-stranded DNA Endodeoxyribonuclease Activity DNA Binding DNA Helicase Activity Double-stranded Telomeric DNA Binding Adenylate Kinase Activity Protein Binding ATP Binding 3'-5' Exonuclease Activity Protein Binding, Bridging Identical Protein Binding Single-stranded Telomeric DNA Binding Metal Ion Binding G-quadruplex DNA Binding	Protein Binding
	Biological Process	Regulation Of Mitotic Recombination Telomere Maintenance Via Recombination Telomere Maintenance Double-strand Break Repair Via Homologous Recombination DNA Double-strand Break Processing DNA Replication DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination Cellular Response To DNA Damage Stimulus Telomere Maintenance Via Telomerase Reciprocal Meiotic Recombination Viral Process Telomere Capping Telomeric 3' Overhang Formation Positive Regulation Of Protein Autophosphorylation Positive Regulation Of Telomere Maintenance DNA Duplex Unwinding Positive Regulation Of Kinase Activity Nucleoside Monophosphate Phosphorylation Chromosome Organization Involved In Meiotic Cell Cycle Nucleic Acid Phosphodiester Bond Hydrolysis Regulation Of Signal Transduction By P53 Class Mediator Negative Regulation Of Telomere Capping	Retrograde Vesicle-mediated Transport, Golgi To ER Cell Cycle Protein Transport Regulation Of ER To Golgi Vesicle-mediated Transport Regulation Of Signal Transduction Involved In Mitotic G2 DNA Damage Checkpoint
Pathways		DNA Damage/Telomere Stress Induced Senescence HDR through Single Strand Annealing (SSA) HDR through MMEJ (alt-NHEJ) HDR through Homologous Recombination (HRR) Sensing of DNA Double Strand Breaks Resolution of D-loop Structures through Synthesis-Dependent Strand Annealing (SDSA) Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Resolution of D-loop Structures through Holliday Junction Intermediates Nonhomologous End-Joining (NHEJ) Homologous DNA Pairing and Strand Exchange Processing of DNA double-strand break ends Presynaptic phase of homologous DNA pairing and strand exchange Regulation of TP53 Activity through Phosphorylation G2/M DNA damage checkpoint Meiotic recombination	COPI-dependent Golgi-to-ER retrograde traffic
Drugs
Diseases		DNA repair defects, including the following six diseases: Ataxia telangiectasia (AT); Ataxia-talangiectasia-like syndrome; Nijmegen syndrome; DNA ligase I deficiency; DNA ligase IV deficiency; Bloom's syndrome
GWAS		Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Asthma ( 20159242 30929738 27611488 27182965 31619474 29273806) Asthma (childhood onset) ( 30929738 24241537 29273806) Asthma (moderate or severe) ( 30552067) Asthma onset (childhood vs adult) ( 30929738) Asthma or allergic disease (pleiotropy) ( 29785011) Atopic dermatitis ( 23886662 25865352 25574825 26482879) Eosinophil counts ( 29403010 27863252) Eosinophil percentage of granulocytes ( 27863252) Eosinophil percentage of white cells ( 27863252) IgE levels ( 18846228) Inflammatory skin disease ( 25574825) Itch intensity from mosquito bite ( 28199695) Neutrophil percentage of white cells ( 27863252) Polycystic ovary syndrome ( 30566500 26416764) Rosacea symptom severity ( 29771307) Sum eosinophil basophil counts ( 27863252) Venous thromboembolism adjusted for sickle cell variant rs77121243-T ( 28203683)
Interacting Genes		10 interacting genes: DCLRE1C EP300 MDC1 MRE11 NBN RECQL5 RINT1 SUMO2 TERF2IP TP53BP1	55 interacting genes: ARNT2 BNIP3L C1orf109 CCDC121 CCDC146 CEP57L1 CSPP1 CWF19L2 DCX EPC1 FAM107A FAM110A FAM124B FAM161A FAM81B FAM90A1 FANCG GFI1B GRAP2 HDAC4 HGS LMO2 LSP1P3 MCM7 PCM1 PIK3R2 PIMREG PRPF31 PSTPIP1 RAD50 RB1 RBL1 RBL2 RBM41 RIBC1 RNF6 RSRC2 RTP5 SCNM1 SFR1 SGF29 SH2D4A SMARCB1 SMARCE1 SNW1 SPTBN1 STRN TEX9 TXLNA VPS37C XPNPEP1 ZNF655 ZNF688 ZNF697 ZW10
Entrez ID		10111	60561
HPRD ID		04950	15250
Ensembl ID		ENSG00000113522	ENSG00000135249
Uniprot IDs		A5D6Y3 Q92878	Q6NUQ1
PDB IDs		5GOX
Enriched GO Terms of Interacting Partners?
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