ABCC5 and SERPINA3

Number of citations of the paper that reports this interaction (PubMedID 21988832)
75

Data Source:
BioGRID (two hybrid)

		ABCC5	SERPINA3
Description		ATP binding cassette subfamily C member 5	serpin family A member 3
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Integral Component Of Plasma Membrane Membrane Basolateral Plasma Membrane	Extracellular Region Extracellular Space Nucleus Platelet Alpha Granule Lumen Secretory Granule Lumen Azurophil Granule Lumen Collagen-containing Extracellular Matrix Extracellular Exosome Blood Microparticle
	Molecular Function	ATP Binding Organic Anion Transmembrane Transporter Activity Efflux Transmembrane Transporter Activity ATPase Activity ATPase Activity, Coupled To Transmembrane Movement Of Substances Xenobiotic Transmembrane Transporter Activity	DNA Binding Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Organic Anion Transport Hyaluronan Biosynthetic Process Xenobiotic Transport Transmembrane Transport Export Across Plasma Membrane	Platelet Degranulation Acute-phase Response Inflammatory Response Negative Regulation Of Endopeptidase Activity Regulation Of Lipid Metabolic Process Maintenance Of Gastrointestinal Epithelium Neutrophil Degranulation
Pathways		Hyaluronan biosynthesis and export ABC-family proteins mediated transport	Platelet degranulation Neutrophil degranulation
Drugs		Curcumin	Zinc
Diseases
GWAS		Anterior chamber depth ( 24603532) Platelet count ( 27863252) Type 2 diabetes ( 30297969)	Blood protein levels ( 30072576 28240269) Body mass index ( 23669352) Prostate-specific antigen levels ( 28139693) Serum total protein level ( 29403010)
Interacting Genes		4 interacting genes: AK2 RBP5 SERPINA3 SMC2	26 interacting genes: ABCC5 ADAMTS4 ADH1B APP CELA1 CMA1 CTRB1 CTRC CTRL CTSG DNAJC1 ELANE ERBB2 F5 HOXB1 KLK13 KLK2 KLK3 KLK4 LAMC3 LMNB1 MMP1 MST1 NFKB1 POLA1 ZNRD1
Entrez ID		10057	12
HPRD ID		06898	00120
Ensembl ID		ENSG00000114770	ENSG00000196136
Uniprot IDs		O15440	A0A024R6P0 P01011
PDB IDs			1AS4 1QMN 2ACH 3CAA 3DLW 4CAA 6HGE
Enriched GO Terms of Interacting Partners?
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