PDCD6 and PDCD6IP

Number of citations of the paper that reports this interaction (PubMedID 9880530)
67

Data Source:
BioGRID (affinity chromatography technology)
HPRD (two hybrid, in vivo, in vitro)

		PDCD6	PDCD6IP
Description		programmed cell death 6	programmed cell death 6 interacting protein
Image
GO Annotations	Cellular Component	Golgi Membrane Nucleus Cytoplasm Endosome Endoplasmic Reticulum Endoplasmic Reticulum Membrane COPII Vesicle Coat Cytoplasmic Vesicle Cul3-RING Ubiquitin Ligase Complex Extracellular Exosome Endoplasmic Reticulum Exit Site	Immunological Synapse Cell Microtubule Organizing Center Cytosol Bicellular Tight Junction Focal Adhesion Membrane Melanosome Actomyosin Intracellular Membrane-bounded Organelle Extracellular Exosome Endoplasmic Reticulum Exit Site Flemming Body Extracellular Vesicle
	Molecular Function	Magnesium Ion Binding Calcium Ion Binding Protein Binding Protein Binding, Bridging Identical Protein Binding Protein Homodimerization Activity Protein Membrane Anchor Protein Dimerization Activity Calcium-dependent Protein Binding Protein Binding, Bridging Involved In Substrate Recognition For Ubiquitination	Protein Binding Proteinase Activated Receptor Binding Protein Homodimerization Activity Calcium-dependent Protein Binding
	Biological Process	Angiogenesis Positive Regulation Of Endothelial Cell Proliferation Intracellular Protein Transport ER To Golgi Vesicle-mediated Transport Activation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Endothelial Cell Migration Neural Crest Formation Neural Crest Cell Development Protein Ubiquitination Negative Regulation Of Vascular Endothelial Growth Factor Receptor Signaling Pathway Negative Regulation Of TOR Signaling Cellular Response To Heat Vascular Endothelial Growth Factor Receptor-2 Signaling Pathway Positive Regulation Of Cysteine-type Endopeptidase Activity Involved In Apoptotic Process Positive Regulation Of Angiogenesis COPII Vesicle Coating Response To Calcium Ion Negative Regulation Of Protein Kinase B Signaling Apoptotic Signaling Pathway Positive Regulation Of Protein Monoubiquitination	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Apoptotic Process Nucleus Organization Mitotic Metaphase Plate Congression Regulation Of Centrosome Duplication Protein Transport Viral Life Cycle Multivesicular Body Assembly Viral Budding Via Host ESCRT Complex Maintenance Of Epithelial Cell Apical/basal Polarity Viral Budding Protein Homooligomerization Midbody Abscission Bicellular Tight Junction Assembly Regulation Of Membrane Permeability Ubiquitin-independent Protein Catabolic Process Via The Multivesicular Body Sorting Pathway Regulation Of Mitotic Spindle Assembly Positive Regulation Of Exosomal Secretion Regulation Of Extracellular Exosome Assembly Positive Regulation Of Extracellular Exosome Assembly
Pathways			Budding and maturation of HIV virion Uptake and function of anthrax toxins
Drugs		Calcium Zinc Calcium Citrate Calcium Phosphate
Diseases
GWAS			Alanine aminotransferase (ALT) levels after remission induction therapy in actute lymphoblastic leukemia (ALL) ( 28090653) Neuroticism ( 27089181) Periodontitis (Mean PAL) ( 24024966) Rosacea symptom severity ( 29771307) Severe influenza A (H1N1) infection ( 26379185) Smoking status (ever vs never smokers) ( 30643258) Visceral adipose tissue adjusted for BMI ( 22589738) White coat effect (clinic diastolic blood pressure minus ambulatory diastolic blood pressure) ( 31044621)
Interacting Genes		20 interacting genes: ANXA11 ANXA7 CDKN2A CPNE1 CPNE2 CPNE4 CUL3 FAS FASLG HEBP2 IGFALS MAP3K5 MAPK1IP1L PDCD6IP PEF1 SEC31A SH3KBP1 TIMM22 VPS37C YWHAQ	34 interacting genes: ARRDC1 ARRDC3 ATN1 CD2AP CEP55 CHMP4A CHMP4B CHMP4C CXCR1 EGFR F2R GRB2 ITSN1 ITSN2 KEAP1 MAPK6 PDCD6 PTK2B RAMP3 RNF11 SDCBP SH3GL1 SH3GL2 SH3GL3 SH3KBP1 SH3RF1 SRC TAB1 TSG101 TTF2 UBC VPS28 VPS37C YES1
Entrez ID		10016	10015
HPRD ID		03035	06425
Ensembl ID		ENSG00000249915	ENSG00000170248
Uniprot IDs		A0A024QZ42 A0A087WZ38 O75340 Q53FC3	Q8WUM4
PDB IDs		2ZN8 2ZN9 2ZND 2ZNE 2ZRS 2ZRT 3AAJ 3AAK 3WXA 5GQQ	2OEV 2OEW 2OEX 2OJQ 2R02 2R03 2R05 2XS1 2XS8 2ZNE 3C3O 3C3Q 3C3R 3E1R 3WUV 4JJY 5V3R 5WA1
Enriched GO Terms of Interacting Partners?
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