MED6 and TARDBP

Number of citations of the paper that reports this interaction (PubMedID 24825905)
21

Data Source:
BioGRID (two hybrid)

		MED6	TARDBP
Description		mediator complex subunit 6	TAR DNA binding protein
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Membrane Mediator Complex Core Mediator Complex	Nucleus Nucleoplasm Perichromatin Fibrils Cytoplasmic Stress Granule Nuclear Speck Interchromatin Granule Ribonucleoprotein Complex
	Molecular Function	Transcription Coactivator Activity Protein Binding Transcription Factor Binding	RNA Polymerase II Proximal Promoter Sequence-specific DNA Binding Double-stranded DNA Binding DNA-binding Transcription Factor Activity RNA Binding MRNA 3'-UTR Binding Protein Binding Identical Protein Binding Sequence-specific DNA Binding Pre-mRNA Intronic Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Regulation Of Transcription By RNA Polymerase II Transcription Initiation From RNA Polymerase II Promoter Positive Regulation Of Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly	Negative Regulation Of Protein Phosphorylation Regulation Of Transcription, DNA-templated Transcription By RNA Polymerase II MRNA Processing RNA Splicing Negative Regulation Of Gene Expression Regulation Of Protein Stability Positive Regulation Of Insulin Secretion Response To Endoplasmic Reticulum Stress Positive Regulation Of Protein Import Into Nucleus Regulation Of Circadian Rhythm Regulation Of Apoptotic Process Negative Regulation By Host Of Viral Transcription Rhythmic Process Regulation Of RNA Metabolic Process Regulation Of Cell Cycle 3'-UTR-mediated MRNA Destabilization 3'-UTR-mediated MRNA Stabilization Nuclear Inner Membrane Organization
Pathways		PPARA activates gene expression Generic Transcription Pathway Transcriptional regulation of white adipocyte differentiation Transcriptional regulation of white adipocyte differentiation
Drugs
Diseases			Amyotrophic lateral sclerosis (ALS); Lou Gehrig's disease
GWAS			Beard thickness ( 26926045) Ewing sarcoma ( 22327514) Male-pattern baldness ( 22693459 28196072)
Interacting Genes		15 interacting genes: BCL6 CTDP1 ESR1 ESR2 MED25 MED8 MED9 PARP1 RARA SMAD1 SMAD2 SMARCA4 SREBF1 SUZ12 TARDBP	17 interacting genes: APP EXOSC10 FBXO7 FUS IRAK2 LSM6 MED6 NACC1 NSFL1C RACK1 RBM45 RNF2 SETDB1 UBQLN1 XRN2 ZFAND2B ZHX1
Entrez ID		10001	23435
HPRD ID		04284	05466
Ensembl ID		ENSG00000133997	ENSG00000120948
Uniprot IDs		A0A087WYL7 O75586	A0A024R4E2 Q13148 Q9H256
PDB IDs			1WF0 2CQG 2N2C 2N3X 2N4G 2N4H 2N4P 4BS2 4IUF 4Y00 4Y0F 5MDI 5MRG 5W50 5W52 5W7V 5WHN 5WHP 5WIA 5WIQ 5WKB 5WKD 5X4F 6B1G 6CF4 6CFH 6N37 6N3A 6N3B 6N3C
Enriched GO Terms of Interacting Partners?
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